Two novel, isomeric compounds, coumamidines gamma 1 and gamma 2, were isolated from fermentations of an actinomycete. The structures were elucidated spectroscopically using 2D NMR correlation experiments and mass spectral data. The coumamidines were found to be close structural relatives of the cinodines (LL-BM123 gamma 1 and gamma 2).

The marine fungus Chondrostereum sp. was collected from a soft coral of the species Sarcophyton tortuosum from the South China Sea. Three new compounds, chondrosterins F-H (1, 4 and 5), together with three known compounds, incarnal (2), arthrosporone (3), and (2E)-decene-4,6,8-triyn-1-ol (6), were isolated. Their structures were elucidated primarily based on NMR and MS data. Incarnal (2) exhibi...

A review is given of the development of the industrial manufacture of carotenoids and vitamin A by isolation and by synthesis. Special emphasis is placed on the use of carotenoids as a preferred class of colouring matters for food and feed. INTRODUCTION A review of the industrial manufacture of carotenoids and vitamin A may be separated into four areas: First the area of isolation and the struc...

Cicer arietinum, Ascochyta rabiei, Elicitor. Isoflavones, Phytoalexins Upon slicing cotyledons of chickpea, Cicer arietinum L ., accumulate the pterocarpan phyto­ alexins medicarpin and maackiain. Treatment of this tissue with an elicitor from the phytopathogenic deuteromycete Ascochyta rabiei (Pass.) Lab. greatly enhances accumulation of the pterocarpans and of other isoflavones and flavonoids...

The chemical and biological diversity of the marine environment is immeasurable and therefore is an extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodologic advances in structure elucidation, organic synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents. These compounds range in st...

search for novel antimicrobial agents from microorganisms, an actinomycete strain Streptomyces sp. isolated from a soil sample collected in Taejon, Korea, was found to produce a new antibacterial 16-methyloxazolomycin (1). In this paper, we describe the production, isolation, structural elucidation and biological activities of 1. The strain was cultured in the seed mediumconsisting of glucose 2...

Haloalkaliphiles are double extremophilic organisms thriving both at high salinity and alkaline pH. Although numerous haloalkaliphilic representatives have been identified among Archaea and Bacteria over the past 15 years, the adaptations underlying their prosperity at haloalkaline conditions are scarcely known. A multi-level adaptive strategy was proposed to occur in haloalkaliphilic organisms...

Platensimycin (1) and platencin (2) are novel antibiotic leads against multidrug resistant pathogens. The production of 2 in Streptomyces platensis MA7339 is under the control of ptnR1, a GntR-like transcriptional regulator. Inactivating ptnR1 afforded S. platensis MA7339 mutant strain SB12600 that overproduces 2 at a titer approximately 100-fold greater than that from the wild-type strain and ...