Recent work (Blundell et al., 2001; Balleine et al., 2003) has suggested that the basolateral region of the amygdala (BLA) is important in the representation of the sensory and incentive aspects of motivationally significant events. In common with other theories of function of the BLA, this predicts that lesions of the BLA will interfere with reinforcer devaluation after appetitive Pavlovian or...

meta-analysis of three randomized clinical trials including ISAT did not show a significant difference in outcomes between patients treated with these two options. Despite limitations of ISAT, this is a wellexecuted trial that highlights the necessity of long-term follow-up in aneurysmal SAH patients. The increased rate of rebleeding in untreated and de novo aneurysms underscores that clipping ...

Vinten-Johansen J, Zhao Z, Jiang R, Zatta AJ, Dobson GP. Preconditioning and postconditioning: innate cardioprotection from ischemia-reperfusion injury. J Appl Physiol 103: 1441–1448, 2007; doi:10.1152/japplphysiol.00642.2007.— Reperfusion is the definitive treatment to salvage ischemic myocardium from infarction. A primary determinant of infarct size is the duration of ischemia. In myocardium ...

Background Accurate quantification of the ischemic myocardium at risk (MaR) in patients with STelevation myocardial infarction (STEMI) is paramount in studies of therapies seeking to reduce infarct size expressed as percent of MaR. Cardiac magnetic resonance (CMR) is an important clinical research tool for determination of MaR and infarct size in the same examination within one week after STEMI...

Myocardial protection from ischemic and reperfusion injury is an important task of modern experimental clinical medicine. This type damage a key link in the pathogenesis coronary heart disease and, above all, acute myocardial infarction – socio-economically significant that one main causes disability mortality adult population Republic Belarus. The aim study was to elucidate cardioprotective ef...

Ischemic postconditioning (IPC) and ATP sensitive potassium channel (KATP) agonists (e.g. pinacidil and diazoxide) postconditioning are effective methods to defeat myocardial ischemia-reperfusion (I/R) injury, but their specific mechanisms of reducing I/R injury are not fully understood. We observed an intracellular free calcium ([Ca2+]i) overload in Anoxia/reoxygenation (A/R) cardiomyocytes, w...

Ischemic postconditioning (PostC) and perconditioning (PerC) provide practical methods for protecting the heart against ischemia-reperfusion (I/R) injury, but their combined effects have not been studied in detail. Using an in vivo rat I/R model, we tested 1) whether additive effects were produced when local PostC was preceded by varying doses of remote PerC, and whether the optimal PostC+PerC ...

introduction: this study was aimed to investigate the effects of postconditioning by natural honey on cardiac arrhythmias in the ischemic isolated rat heart. methods: male wistar rats were divided into four groups then anesthetized by sodium pentobarbital. the animal hearts were removed and quickly mounted on a langendorff apparatus and perfused under constant pressure by a modified krebs-hense...