BACKGROUND/AIMS Renal ischemia/reperfusion injury (IRI) is a very common clinical event and usually leads to ischemic acute renal failure (ARF). In the present study, we investigated the protective role of vitamin C in renal function and renal arterial relaxation following ischemic injury. METHODS IRI model in mice was used. Various biochemical parameters including nitric oxide (NO), reduced ...

Renal ischemia/reperfusion injury (IRI) frequently complicates shock, renal transplantation and cardiac and aortic surgery, and has prognostic significance. The translocation of phosphatidylserines to cell surfaces is an important pro-inflammatory signal for cell-stress after IRI. We hypothesized that shielding of exposed phosphatidylserines by the annexin A5 (ANXA5) homodimer Diannexin protect...

Abstract Background and Aims Acute kidney injury (AKI) is a life-threatening condition. The absence of oxygen during the acute ischemic phase would disturb energy metabolism cause tubular epithelial cell damage. Fatty Acid Oxidation (FAO) main source production renal proximal cells. Timely promoting FAO, increasing supplies energy, proliferation are essential to improve injury, but there no cli...

This study aims to observe the changes and the function of p38MAPK-HSP27 signaling pathways in acute lung injury (ALI) induced by acute ischemic kidney injury in rats. Wistar rats were randomly divided into Group A (control group), Group B (acute kidney injury group), and Group C (acute kidney injury +SB203580). The concentration of protein in BALF, neutrophil counts, PI, W/D; the concentration...

INTRODUCTION This study reports a novel strategy for investigating the key factors responsible for the protective effect of remote ischemic preconditioning (RIPC) against renal ischemia-reperfusion (IR) injury, which remains the leading cause of the acute kidney injury that increase the morbidity and mortality in patients with renal impairment. METHODS The renal blood flow of the right kidney...

occupational exposure to toluene is associated with development and progression of renal failure. however, the cellular mechanisms by which these agents cause renal dysfunction and injury remain elusive. the present study investigates the effect of toluene on animal model (rat) kidney to present a broader understanding of the mechanism by which toluene causes renal injury. adult male rats recei...

Various recent studies reveal that many autoinflammatory syndromes result from inflammasome related protein abnormality. Some inflammasomes closely correlate with caspase 1. Caspase 1 is a key molecule for activation of IL-1β, which is responsible for induction and augmentation of inflammation. Inflammatory cytokines, including IL-1β, are necessary for TH17 differentiation from TH0 cell. TH17 c...

Abstract Background and Aims Acute kidney injury (AKI) is a life-threatening condition. The absence of oxygen during the acute ischemic phase would disturb energy metabolism cause tubular epithelial cell damage. Fatty Acid Oxidation (FAO) main source production renal proximal cells. Timely promoting FAO, increasing supplies energy, proliferation are essential to improve injury, but there no cli...

Correspondence: Mohamed S. A. Mohamed, MBBCh, MSc, MD. Thoracic Transplantation Department, University Clinic Essen, Germany, Hufeland Straße 55. D-45147 Essen. Email:[email protected] Ischemic preconditioning is a technique where prior application of repeated short cycles of ischemia and reperfusion would be able to attenuate the severity of the subsequent ischemic reperfusion injur...

BACKGROUND/AIM Fas ligand (FasL) and tumor necrosis factor (TNF)-α are major pro-apoptotic molecules and also induce inflammation through cytokine and chemokine production. Although precise intracellular mechanisms of action have been reported for each molecule, the differential impact of these molecules on kidney injury in vivo still requires clarification. METHODS We explored the differenti...