OBJECTIVE To determine whether there is an independent association between infection with Chlamydia pneumoniae and ischaemic heart disease. DESIGN Prospective study using a nested case-control design. SETTING Medical centre in London run by BUPA, a private medical organisation. PARTICIPANTS 21 520 professional men aged 35-64 who attended for a medical examination in London between 1975 an...

Platelet adhesiveness was measured in vitro in a group of patients with ischaemic heart disease and in a group of matched healthy subjects using either 1% EDTA or 3.8% sodium citrate as anticoagulant. When sodium citrate was used platelet adhesiveness was significantly greater in the group with ischaemic heart disease. However, no difference was found when EDTA was used. In both groups platelet...

BACKGROUND The pathogenesis of haemodialysis-induced hypotension is multifactorial and may include autonomic nervous system dysfunction. The present study was undertaken to (i) determine heart rate variability (HRV) in chronic haemodialysis patients without and with haemodynamic instability (hypotension-prone) during ultrafiltration and (ii) identify patients at risk and the predictors of dialy...

1. To recognise that acute myocardial ischaemia/reperfusion injury is a neglected therapeutic target for cardioprotection that is responsible for the ongoing morbidity and mortality of patients with ischaemic heart disease. 2. To be aware that cardiac bypass surgery and STEMI are the major clinical settings in which the heart is subjected to acute ischaemia/reperfusion injury. 3. To be familiar...

The term 'therapeutic angiogenesis' originated almost two decades ago, following evidence that factors that promote blood vessel formation could be delivered to ischaemic tissues and restore blood flow. Following this proof-of-principle, safety and efficacy of the best-studied angiogenic factors (eg, vascular endothelial growth factor) were demonstrated in early clinical studies. Promising resu...

Serum Uric Acid was done in 150 male patients suffering from ischaemic heart disease (angina pectoris 67 and myocardial infarction 83) and 30 controls. Serum Uric Acid was significantly raised (P <0.001) in patients as compared to controls. It is suggested that in assessing the suscéptibility of a person to ischaemic heart disease (IHD) serum uric acid Values should beconsidered as a predictor ...

A study was made of the diagnostic value of the atrial sound in ischaemic heart disease. It is shown that in ischaemic heart disease, whether or not infarction has occurred, an atrial sound is usually present and can be detected both clinically and phonocardiographically. Its absence makes the presence of ischaemic heart disease unlikely. In a clinical series of 276 consecutive cases of myocard...