Fragmentation behavior of two classes of cyclodepsipeptides, isariins and isaridins, obtained from the fungus Isaria, was investigated in the presence of different metal ions using multistage tandem mass spectrometry (MS(n)) with collision induced dissociation (CID) and validated by NMR spectroscopy. During MS(n) process, both protonated and metal-cationized isariins generated product ions belo...

FTY720, a new chemical substance derived from the ascomycete Isaria sinclairii, is used for treating multiple sclerosis, renal cancer, and asthma. Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid metabolite and exists in red blood cells. FTY720 is a synthetic S1P analog which can block S1P evoking physiological effects. Recently studies show that S1P was participating in activated infl...

FTY720 is a novel immunosuppressive drug derived from a metabolite from Isaria sinclairii that is known to induce apoptosis of rat splenic T cells. In this study, we examined the intracellular signaling pathway triggered by FTY720. Treatment of human Jurkat T lymphocytes with FTY720-induced apoptosis characterized by DNA fragmentation. The same treatment induced activation of protein kinases su...

Abstract Ten strains of entomopathogenic ascomycete fungi, sourced from commercial formulations blastopore or conidiospore formulations, were tested in 14 different a primary acquisition/direct spray bioassay against adult Asian citrus psyllid ( Diaphorina citr i Kuwayama (Hemiptera: Liviidae)). The Cordyceps Isaria ) javanica Apopka 97-C (conidia) strain was used as the standard. A statistical...

In the present study, a total of 17 indigenous entomopathogenic fungal (EPF) isolates (Beauveria bassiana (Bals.) Vuill. – 14, Clonostachys rosea (Link) Schroers 2, Isaria farinosa (Holmsk.) Fr. 1) obtained from soil samples collected Antalya province (southwestern part Turkey) and three commercial EPF products [i.e. Priority® (Paecilomyces fumosoroseus), Nibortem® (Verticillium lecanii) Nostal...