Context. In the BHR71 region, two low-mass protostars IRS1 and IRS2 drive two distinguishable outflows. They constitute an ideal laboratory to investigate both the effects of shock chemistry and the mechanisms that led to their formation. Aims. We aim to define the global morphology of the warm gas component of the BHR 71 outflow and at modelling its shocked

Clinical studies suggest a link between peripheral insulin resistance and cognitive dysfunction. Interestingly, post-mortem analyses of Alzheimer disease (AD) subjects demonstrated insulin resistance in the brain proposing a role for cognitive deficits observed in AD. However, the mechanisms responsible for the onset of brain insulin resistance (BIR) need further elucidations. Biliverdin reduct...

Insulin resistance is a major underlying mechanism responsible for the ‘metabolic syndrome’, which is also known as insulin resistance syndrome. The incidence of metabolic syndrome is increasing at an alarming rate, becoming a major public and clinical problem worldwide. Metabolic syndrome is represented by a group of interrelated disorders, including obesity, hyperglycemia, hyperlipidemia, and...

Short-term muscle denervation is a reproducible model of tissue-specific insulin resistance. To investigate the molecular basis of insulin resistance in denervated muscle, the downstream signaling molecules of the insulin-signaling pathway were examined in intact and denervated soleus muscle of rats. Short-term denervation induced a significant fall in glucose clearance rates (62% of control, P...

Saturated fatty acids, such as palmitate, promote accumulation of ceramide, which impairs activation and signalling of PKB (protein kinase B; also known as Akt) to important end points such as glucose transport. SPT (serine palmitoyl transferase) is a key enzyme regulating ceramide synthesis from palmitate and represents a potential molecular target in curbing lipid-induced insulin resistance. ...

We were delighted to read the recent report by Courneya and colleagues on the 1-year feasibility and fitness benefits of a structured exercise program among colon cancer survivors in the CHALLENGE Trial (1). These findings, and the expected 3-year follow-updata, are an important contribution to thenascent body of research examining the effectiveness of sustained exercise behavior change in canc...