Irisin is a novel hormone that provides possible solution for the treatment of metabolic disorders. Discovered in 2012 by Boström et al., irisin very quickly became an interesting subject medical research. has been found cerebrospinal fluid, cerebellum, thyroid, pineal gland, liver, pancreas, testis, spleen, adult stomach, and human fetuses. Regarding actions irisin, both animals humans, result...

Background: Irisin is a recent myokine that decreases obesity and enhances insulin resistance by converting white adipose tissues to brown, leading increase thermogenesis lower resistance. Objective: The impact of moderate swimming exercise combined with dietary vitamin D on serum irisin levels was evaluated in type II diabetes rat model (T2DM). Material Methods: This study conducted between Se...

OBJECTIVE Irisin, a newly discovered myokine, can drive the browning of white adipocytes to control body weight or mitigate obesity progression through regulating energy metabolism. However, the underlying mechanisms or specific signal pathways of exercise-induced irisin on the management of obesity are still unclear. MATERIALS AND METHODS Totally 30 rats were subjected to high fat diet (HFD)...

The study investigated changes in myokines, heat shock proteins, and growth factors in highly ranked, young, male tennis players in response to physical workload during the competitive season and their potential correlations with match scores. Blood collections were carried out at the beginning, the midpoint, and the end of the tournament season. Data analysis revealed a significant increase in...

Although progress has been recently made in understanding of inflammatory bowel diseases (IBD), their etiology is unknown apart from several factors from adipose tissue and skeletal muscles such as cytokines, adipokines, and myokines were implicated in the pathogenesis of ulcerative colitis. We studied the effect high-fat diet (HFD; cholesterol up to 70%), low-fat diet (LFD; cholesterol up to 1...

In addition, there was a typographical error in the Abstract. " Inhibition of p38 MAPK by SB023580 or pERK by U0126 abolished the proliferation and up-regulatory effects of irisin on Runx 2 expression and ALP activity. " now reads " Inhibition of p38 MAPK by SB203580 or pERK by U0126 abolished the proliferation and up-regulatory effects of irisin on Runx 2 expression and ALP activity. " These e...

Exercise can improve cognitive function and has been linked to the increased expression of brain-derived neurotrophic factor (BDNF). However, the underlying molecular mechanisms driving the elevation of this neurotrophin remain unknown. Here we show that FNDC5, a previously identified muscle protein that is induced in exercise and is cleaved and secreted as irisin, is also elevated by endurance...

Objective: Obstructive sleep apnea syndrome (OSAS) is a common disorder that caused by the reduction or cessation of airflow in upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are three significant factors metabolic process human body. The objective this study was to investigate whether plasma irisin, RBP-4, levels associated with severity OSAS. Methods: According inclu...

Osteoporosis, the skeletal disease characterized by decrease of bone mass and deterioration of its microarchitecture, and Sarcopenia, the muscle disease characterized by progressive loss of muscle mass and strength, are often concurrent diseases affecting the elderly population. These associated pathologies represent one of the major threats that increase the risk of fall-related fracture durin...