BACKGROUND Metabolic syndrome (MetS) is the major risk factor for development of type 2 diabetes and cardiovascular diseases in different populations. The aim of this study was to evaluate the prevalence of MetS among Iranian population. METHODS Thirty-four cross-sectional studies were analyzed with a sample of 83227 people. National and international English electronic databases (PubMed, Goo...

Purpose/Background. Mounting evidence designates that HLA-G plays a role in the regulation of inflammatory processes and autoimmune diseases. There are controversial reports concerning the impact of HLA-G gene polymorphism on rheumatoid arthritis (RA). This study was aimed at examining the impact of 14 bp ins/del and +3142G>C polymorphism with susceptibility and early disease activity in RA pat...

BACKGROUND MDM2 (Murine Double Minute2) is an oncoprotein that inhibits the P53 activity. Overexpression of MDM2 gene has been reported in several human tumors. In the present study, we aimed to evaluate the impact of 40-bp insertion/deletion (ins/del) polymorphism on the promoter of MDM2 and susceptibility to breast cancer in a sample of Iranian population. METHODS This case-control study wa...

BACKGROUND Reproductive morbidity has a huge impact on the health and quality of life of women. We aimed to determine the prevalence of reproductive morbidities and the health seeking behavior of a nationally representative sample of Iranian urban women. METHODS A sample of 1252 women, aged 18-45 years, was selected using the multi stage, stratified probability sampling procedure. Data were c...

Received: 22/Jul/2008, Accepted: 8/Mar/2009 Objective: Thiopurine S-methyltransferase (TPMT) catalyses the S-methylation of thiopurine drugs. Low activity phenotypes are correlated with several mutations in the TPMT gene and adverse drug reactions. The molecular basis for dissimilar enzymatic activity of TPMT has been established in Caucasians, African-Americans and Southwest Asians, but it rem...

OBJECTIVE This study is an attempt to identify and specify the differences among five major Iranian ethnic groups, i.e. Persian, Azeri, Kurd, Lur, and Arab regarding their awareness, understanding and attitudes towards epilepsy and their beliefs about the treatment of epilepsy. METHOD This survey was carried out cross-sectionally on a sample containing 500 participants from five major ethnic ...

INTRODUCTION Premature ejaculation (PE) is one of the most prevalent male sexual problems. The Premature Ejaculation Diagnostic Tool (PEDT) is a suitable patient-reported outcome measure for the assessment of PE. AIM To examine the psychometric proporties of a translated and culturally adapted version of the PEDT in a sample of Iranian men suffering from PE. METHODS Two independent samples ...

INTRODUCTION Studies indicate that hypertension is prevalent in Iran, however, the reports are heterogeneous. The aim of this study was to estimate the incidence of hypertension and the rate of follow-up in a sample of population over 30 years old in Kashan city. METHODS A descriptive study was conducted on people screened for hypertension in the project of "monitoring the health of Iranian p...

Flap endonuclease 1 (FEN1), a DNA repair protein, is important in preventing carcinogenesis. Two functional germ line variants -69G>A (rs174538) and +4150G>T (rs4246215) in the FEN1 gene have been associated with risk of various types of cancer. The aim of the present study was to evaluate the possible impact of FEN1 polymorphisms on risk of breast cancer (BC) in a sample of Iranian subjects. T...

BACKGROUND While many researchers often use a theoretical framework for mammogram repeat interventions, it seems they do not apply an identified mediation analysis method. The aim of this study was to determine the mediators of mammogram replication behavior in two tailored interventions for non-adherent Iranian women. MATERIALS AND METHODS A sample population of 184 women over 50 years old i...