Ipratropium bromide is a muscarinic receptor antagonist used worldwide for management of chronic obstructive pulmonary disease (COPD) and acute asthma. It is considered a safe drug. Most common anticholinergic adverse effects are dry mouth, constipation and urinary retention. Cardiac and respiratory disorders are considered rare. We report a case of acute coronary syndrome secondary to its use....

Cholinergic antagonists have been used since the early 1900s as bronchodilators for chronic obstructive pulmonary disease (COPD). The present study investigated whether an oral muscarinic M3-selective anticholinergic agent (OrM3) would provide an improved therapeutic advantage compared with an inhaled anticholinergic agent in patients with COPD. A 6-week, multicentre, randomised, placebo- and a...

The effects of three different regimens of inhaled bronchodilators on spirometry and respiratory impedance as measured with the technique of forced oscillations were compared in a double-blind crossover study in 22 patients with stable chronic obstructive pulmonary disease (FEV1 less than 70 percent predicted). On three trial days, patients inhaled, in random order, 40 micrograms ipratropium br...

This study evaluates the effect of three different bronchodilators (beta 2-adrenergic, anticholinergic and methylxanthine) alone and in randomized sequence, during an exacerbation in thirteen patients with chronic obstructive pulmonary disease. Dose-response curves were obtained for inhaled salbutamol and inhaled ipratropium bromide. The bronchodilator effect of a perfusion of aminophylline was...

Background: Bronchiolitis is a viral mediated disease that results in acute inflammation the lower respiratory tract. It occurs infants and children under 2 years of age. The vast majority infants’ experience at least 01 episode bronchiolitis 2-3% all can be hospitalized for 1st year. With an increasing rate having risen by average 1.8% annually European country small percentage even need criti...