Abstract Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization hydrazones in the presence hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, ability to activate HSF1 was investigated. The compounds shown increase degree activation. It that can be used induce Hsp70 expression decrease extent mutant HT...

The response tomethimazole(l-methyl-2-mercaptoimidazol,MMl) therapy was evaluated in 18 patients with diffuse toxic goitre residing in an area of iodine deficiency(Tehran)and in 18 such patients residing in an area of iodine sufficiency(Boston) .Free T4 index(FT4I) decreased from 22.9± 4.8 to 4.9± 4.3 in Tehran and from 23.8± 5.2 to 17.0±4.1 in Boston, 4 weeks after administration of MMl 10 mg ...

Two general classes of compounds interfere with the synthesis of the hormone thyroxine in the thyroid gland. These are the thiocarbamides and what will be referred to here as the “aromatic” antithyroid compounds. The present state of knowledge on the mechanism and locus of action of these substances has been reviewed recently (l-3). There appears to be general agreement that the thiocarbamides ...

Until recently, no generally applicable oxidizing reagents were known for P(III) compounds, al­ though P(III) compounds are readily oxidized to form the corresponding P(V) compounds. All of the oxidizing reagents that were tested, e.g. hydro­ gen peroxide [1], aqueous iodine [2], nitrogen ox­ ides [3], 3,3-dimethyloxirane, stilbenene ozonide [4], m-chlorperbenzoic acid [5], tetrabutylammonium p...

Algae are becoming a strategic source of fuels, food, feedstocks, and biologically active compounds. This potential has stimulated the development of innovative analytical methods focused on these microorganisms. Algal lipids are among the most promising potential products for fuels as well as for nutrition. The crucial parameter characterizing the algal lipids is the degree of unsaturation of ...

BACKGROUND Polyfluorinated iodine alkanes (PFIs) are important intermediates in the synthesis of organic fluoride products. Recently, PFIs have been detected in fluoropolymers as residual raw materials, as well as in the ambient environment. OBJECTIVES High production volumes and potential environmental releases of PFIs might become a concern, but the exposure risk and toxicity of these chemi...

The clinical picture of acute thyroiditis 8 may be so classical that the diagnosis is obvious. However, very often, the symptomatology may be obscure. Several investigators have sought for a laboratory test, specific for the disease, to complement the clinical observations. In 1949, Werner, Quimby, and Schmidt (1) reported that six patients with thyroiditis had exceedingly low thyroidal uptakes...

It is well known that isotopic exchange of iodine in melt is a good approach to iodine labelling when the exchange in solution can not conveniently be achieved''. The advantage of this method is very efficient and rapid labelling technique, and the ease of preparation for labelling without addition or removal of solvent. However, it essentially required that the compound of interest is to be st...