OBJECTIVE Recent data suggest that pretreatment HPV (Human papillomavirus) viral load is useful to predict the severity of intraepithelial lesions of the uterine cervix and formulate a treatment plan. However, the relationship between initial HPV viral load and prognosis of cervical cancer patients has not yet been clearly defined. The objective of this study was to determine whether HPV viral ...

BACKGROUND Oropharyngeal squamous cell carcinomas (OSCCs) are associated with high-grade human papillomavirus (HPV) infection in 20% to 30% of cases. HPV-16 DNA has been detected in cervical lymph node metastases of HPV-16(+) OSCC. However, the meaning of HPV-16 DNA detection in lymph nodes remains controversial. Does the presence of HPV-16 DNA in lymph nodes correlate with their metastatic inv...

Testing auction mechanisms experimentally in a controlled environment provides an inexpensive means for evaluating their relative merits. This paper describes a framework for testing the efficacy of a price-responsive load on a uniform price last accepted offer and a soft-cap market. Experimental evidence to date based on uniform price market testing has shown an ability of price responsive loa...

This study was designed to assess the impact of social support on poststressor cognitive impairment, with the goal of providing a laboratory test of the buffering hypothesis of social support. High or low support was operationahzed as the warm or the neutral behavior of an interviewer, which preceded the experimental stressor, high or low task load Subjects were 32 nonpsychotic female psychiatr...

A series of studies conducted 20 years ago, documenting the cardiac hypertrophy phenotype and its underlying signaling mechanism induced by angiotensin II (Ang II) and mechanical stress, showed a remarkable similarity between the effect of the Gαq agonist and that of mechanical forces on cardiac hypertrophy. Subsequent studies confirmed the involvement of autocrine/paracrine mechanisms, includi...

The complex-arithmetic performance of three different populations was tested: Flemish-speaking Belgians; Englishspeaking Canadians; and Chinese-speaking Chinese participants currently living in Canada. All participants solved complex addition problems (e.g., 58 + 73) under no-load and load conditions, in which one component of working memory (either the central executive or the phonological loo...

BACKGROUND Adrenaline auto-injectors (AAI) should be provided to individuals considered to be at high risk of anaphylaxis. There is some evidence that the rate of AAI prescription is increasing, but the true extent has not been previously quantified. AIM To estimate the trends in annual GP-issued prescriptions for AAI among UK children between 2000 and 2012. DESIGN AND SETTING Retrospective...

BACKGROUND Anaphylaxis is a medical emergency that requires the intramuscular injection of adrenaline using an adrenaline auto-injector (AAI). This study compared the robustness and performance characteristics of three AAIs available in Europe. METHODS Three AAIs (Jext(®), EpiPen(®), and Anapen(®)) were tested in terms of the force needed to activate the AAIs, exposed needle length, injection...