BACKGROUND Increasing the number of patients participating in research studies is a current priority in the National Health Service (NHS) in the United Kingdom. The role of specialist nurses in inviting patients to participate is important, yet little is known about their experiences of doing so. The aim of this study was to explore the perceptions of barriers and facilitators held by specialis...

We would like to begin by congratulating the authors on their fine paper. Handling highly correlated variables is one of the most important issues facing practitioners in highdimensional regression problems, and in some ways it is surprising that it has not received more attention up to this point. The authors have made substantial progress towards practical methodological proposals, however, a...

We would like to start by congratulating the authors for having written this important paper. Prediction intervals are popular in economics and finance (e.g. they are often used by Central Banks to measure point forecasts uncertainty). The paper provides a unifying treatment of bootstrap prediction intervals for autoregression models, which are one of the workhorse models for economic forecasti...

1A. What is the nature of the condition or illness? In Case A, follow-up consultations after cancer surgery and routine consultations for young adults with diabetes were fairly predictable and consistent; the few unpredictable eventualities were low-risk. In contrast, diabetes in pregnancy is a volatile condition and if poorly controlled can lead to fetal malformations or death. The physician f...

Thank you for inviting me to give this year’s Desmond Whyte lecture and for the President’s very kind introduction. It is a great honour to give this lecture, and particularly in Altnagelvin hospital where I spent many Wednesdays in outpatients seeing families with genetic disorders, and regularly availed of the excellent radiology service that Desmond had set up some years ago. The title of th...

The feeling of being utterly lost that is cultivated by David Lynch’s Inland Empire (2006), one a handful films central to Dominic Lash’s Cinema Disorientation: Inviting Confusions, might be the paradigmatic effect body work Lash refers as “cinema disorientation”. These insistently problematise viewer’s relation unfolding diegesis, leaving them without stability interpretive points re...