OBJECTIVES The rate of falling among older citizens appears to vary across different countries, but the underlying aspects causing this variation are unexplained. We aim to describe between-country variation in falling and explore whether intrinsic fall risk factors can explain possible variation. DESIGN Prospective study on data from the cross-national Survey of Health, Ageing and Retirement...

Genetically identical cell populations exhibit considerable intercellular variation in the level of a given protein or mRNA. Both intrinsic and extrinsic sources of noise drive this variability in gene expression. More specifically, extrinsic noise is the expression variability that arises from cell-to-cell differences in cell-specific factors such as enzyme levels, cell size and cell cycle sta...

BACKGROUND Whether cardiac reinnervation occurs after transplantation remains controversial. If reinnervation does occur, how sympathetic and parasympathetic efferent neurons do this remains unknown. METHODS Power spectral analysis of heart rate variability was assessed for 1 year after cardiac autotransplantation in 9 dogs. After induction of anesthesia 13 months after transplantation, cardi...

Elucidation of the rate-determining process in the overall hepatic elimination of drugs is critical for predicting their intrinsic hepatic clearance and the impact of variation of sequestration clearance on their systemic concentration. The present study investigated the rate-determining process in the overall hepatic elimination of the HMG-CoA reductase inhibitors pravastatin, pitavastatin, at...

The intrinsic decay rate of orthopositronium formed in SiO2 powder is measured using the direct 2γ correction method such that the time dependence of the pick-off annihilation rate is precisely determined using high energy-resolution germanium detectors. As a systematic test, two different types of SiO2 powder are used with consistent findings. The intrinsic decay rate of orthopositronium is fo...

The rate-dependent fracture behavior of a 10-phr rubber-modified epoxy was investigated using double-cantilever-beam tests at various crosshead speeds. Dramatic rate effects were observed in the R-curve behavior and in the relationship between the applied energy-release rate and the crack velocity. Furthermore, a transition between fracture with toughening mechanisms operating (kinetic crack gr...

the effects of some synthetic sweeteners on the rheological and physical properties of guar gum in dilute solutions were investigated.measurements include the determination of intrinsic viscosity and the particle size, surface weighted mean [d3, 2], volume weighted mean [d4,3] and specificsurface area ofguar gum andsyntheticsweeteners mixtures. the concentration of these sweeteners were 0, 0.1,...

We find that, in contrast to most viscoelastic polymers previously studied, the intrinsic fracture toughness of vitrimer strongly depends on loading rate while its bulk dissipation associated with crack extension has weak rate-dependence.

To determine whether the molecular configuration of vitamin B(12) influences the attachment of intrinsic factor-vitamin B(12) complex to ileal microvillous membrane receptor sites, we have examined the kinetics of uptake of intrinsic factor-bound cyanocobalamin by brush borders and microvillous membranes isolated from guinea pig ileum, and have compared this uptake with that of intrinsic factor...

The effects of some synthetic sweeteners on the rheological and physical properties of guar gum in dilute solutions were investigated.Measurements include the determination of intrinsic viscosity and the particle size, surface weighted mean [D3, 2], volume weighted mean [D4,3] and specificsurface area ofguar gum andsyntheticsweeteners mixtures. T...