Germinal matrix-intraventricular haemorrhage (GMH-IVH) remains a serious problem in the very and extremely preterm infant. This article reviews current methods of diagnosis, treatment and neurodevelopmental outcome in preterm infants with low-grade and severe GMH-IVH. We conclude that there is still no consensus on timing of intervention and treatment of infants with GMH-IVH, whether or not com...

During an outbreak of Flavobacterium meningosepticum septicaemia in a neonatal intensive care unit 9 infants were treated with intravenous trimethoprim sulphamethoxazole. Bacteriological cure was achieved in 8 patients; one infant died of massive intraventricular haemorrhage on the first day of treatment. Apart from prolonged persistence of pre-existing thrombocytopenia there was no evidence of...

Primary intracerebral haemorrhage (ICH) results in significant morbidity and mortality among patients. There is a paucity of epidemiological data on this condition in Malaysia. The purpose of this hospital based study was to define the clinical profile in patients with primary spontaneous intracerebral haemorrhage at University of Malaya Medical Centre (UMMC) and to determine the mortality rate...

The usual causes of obstruction at the foramen of Monro are neoplasm of the 3rd ventricle, ventriculitis, intraventricular haemorrhage, arteriovenous malformation, subependymal gliosis and overdrainage of one lateral ventricle following a shunt operation. resulting in functional occlusion of the foramen of Monro (1-4,7-11,13).Congenital atresia of the foramen of Monro is rare (12·14). Obstructi...

A wide variety of neurological syndromes have been described following hymenoptera sting like encephalopathy, myeloradiculopathy, optic neuropathy, seizures, parkinsonism, exacerbation of multiple sclerosis, myasthenia gravis, encephalomyelopolyradiculoneuritis and obsessive compulsive behaviour. While petechial haemorrhages, cerebral edema, meningeal hyperemia and intraventricular haemorrhage ...

There is a high incidence of hypoxic-ischaemic brain injury and intraventricular haemorrhage in newborn infants, particularly those born preterm. Many die during the newborn period or suffer permanent neurodevelopmental handicaps. Hypoxic brain injury develops over several hours and could potentially be influenced by intervention. At present, no drug exists that effectively prevents infant brai...

The primary necropsy finding are presented for 726 perinatal deaths; the classification of the 1958 British Perinatal Mortality Survey is used, and results of the two surveys are compared. Lethan malformation has replaced intrapartum hypoxia as the most common cause of perinatal death. There has been substantial reduction in intracranial trauma but an increase in intraventricular haemorrhage an...

Parenteral nutrition (PN) in VLBW premature neonates is one of the most important treatment regimes in the early life. Though it is proved as a lifesaving option, but still there are several opinions on its administration. Some researches support the early administration, whereas other supports late one. In this study we hypothesize that early PN has associated with comparative beneficial impro...