OBJECTIVES Some propofol emulsion formulations contain EDTA or sodium metabisulfite to inhibit microbe growth on extrinsic contamination. EDTA is not known to react with propofol formulation components; however, sulfite has been shown to support some oxidation processes and may react with propofol. This study compared the oxidation of propofol and the formation of free radicals by electron para...

Hydrophobic interaction chromatography (HIC) is presented as a suitable method to determine the surface hydrophobicity of colloidal drug carriers. The experimental design is described in great detail Results obtained with surface-modified polystyrene particles as model carriers and parenteral fat emulsions are discussed as examples. HIC was able to distinguish between particles chemically modif...

Several important enzymatic reactions occurring in nature, such as, e.g., the digestion of fat, proceed only at the interface of two immiscible phases. Typically, these systems consist of an organic substrate, dispersed in an aqueous continuous phase, with a specialized enzyme capable of working at the interface. For adopting such a system for organic synthesis, a stable heterophase system with...

• Thickener type modifies apparent viscosity of emulsified systems under oral conditions. Lubrication properties depend on thickener concentration. Oral oily coating is more related to the oil droplets size than type. Nanoemulsions can be used as an alternative increase fat-related mouth sensations. Food behavior during processing plays essential role in perception texture. It depends different...

Abstract Plant-based emulsion gels can be used as solid animal fat substitutes for vegan sausages. For this reason, commercially available protein isolates with different amino acid profiles from pea, soy and potato (Pea-1, Pea-2, Soy, Potato) have been tested their ability to form shape stable emulsions at neutral pH upon heating 72 °C. In order obtain that are possible, the concentrations in ...

Lipid-based drug delivery systems in the form of triglyceride emulsions, micellar systems and liposomes have been used for parenteral administration for the last few decades. Large number of new chemical entities (NCE) presents formulation and bioavailability problems because of the dose and poor solubility in solvent and co-solvent systems. In addition, high drug concentrations can lead to irr...

Lipid oxidation is the main hurdle for omega-3 fatty acid enrichment in food and beverages. Fat reduces quality safety of supplemented products. A tuna oil-in-water emulsion (20% v/v) was exposed to iron-induced oxidation. Emulsions with changing emulsifiers buffers were analyzed under different storage conditions (argon purging, pH variation) using Conjugated Dienes Thiobarbituric reactive sub...