BACKGROUND Sodium valproate (SV) has been approved for migraine prophylaxis and its intravenous form is used to treat acute migraine attacks. We compared the efficacy and safety of intravenous SV and subcutaneous Sumatriptan in managing acute migraine attacks. METHODS This double-blind randomized clinical trial divided 90 patients into two groups: one group received 400 mg of intravenous SV a...

Ethanol decreases the clearance of cocaine by inhibiting the hydrolysis of cocaine to benzoylecgonine and ecgonine methyl ester by carboxylesterases, and there is a large body of literature describing this interaction as it relates to the abuse of cocaine. In this study, we describe the effect of intravenous ethanol on the pharmacokinetics of cocaine after intravenous and oral administration in...

The problem of patient non-compliance in the management of tuberculosis (TB) can be overcome by reducing the dosing frequency of antitubercular drugs (ATD) employing drug carriers. This study reports on the intravenous (iv) administration of lung specific stealth liposomes encapsulating ATD (rifampicin and isoniazid in combination) to guinea pigs and the detailed pharmacokinetic/chemotherapeuti...

In a double-blind study of on-demand intravenous analgesia buprenorphine was found to be about 600 times as potent as pethidine. The incidence of side effects was similar with both drugs. The quality of analgesia, subjectively assessed, was good with both drugs using this method of administration. Provided that its low potential for abuse is substantiated, buprenorphine appears to be a powerful...

abstract several medications have been proposed as the first line drugs in the treatment of migraine attack. however, the low efficacy, potential complications of medications and the intolerance of some patients for oral route due to nausea and vomiting establish a difficult situation in some migraine patients. this report describes a dramatic pain relief with 60 mg of intravenous propofol in a...

abstract necrotizing fasciitis is a rare, life-threatening infection most commonly seen in patients with diabetes mellitus, intravenous drug abuse, and immunocompromised conditions. the extremities are the primary sites of involvement in as many as two thirds of the cases. in a significant proportion of patients, the extremities are involved as a result of trauma, needle puncture or extravasati...

drug and intravenous thrapy basic clinical skills in nursing students at the end of third year     haji hossaini f [1] *, sharifnia sh [2] , nazari r [3] , rezaei r [4] ,saatsaz s [5]     received: 9 sep, 2011 accepted: 20 oct, 2011     abstract:   background & aims : learning drugs and intravenous therapy are necessary for nursing students. this study was done with the aim of assessing the dru...

Occipital lobe infarcts, hemorrhages, or metastatic tumors can present with complex visual hallucinations, sensory or proprioceptive abnormalities, speech dysfunction, visual loss, and homonymous hemianopia (HH). Treatment of occipital lobe seizures is by single or multiple antiepileptic drugs. We present a case of idiopathic occipital lobe epilepsy where the seizures were controlled by antiepi...

BACKGROUND Nerve injury that produces behavioral changes of allodynia and hyperalgesia in animals is associated with electrophysiologic changes in dorsal root ganglion (DRG) cells. The introduction of drugs into the DRG or the peripheral nerve that alter calcium, sodium, or potassium channel activity may be of therapeutic benefit after nerve injury. For this reason, the authors sought to determ...

OBJECTIVE To examine variation in patients' access to a set of cancer drugs through publicly funded provincial drug programs. DATA SOURCES/STUDY DESIGN We surveyed provincial drug program managers about their highest-expenditure intravenous and oral cancer drugs. We then investigated whether the same cancer drugs account for the highest expenditures across the provincial programs. We also com...