Intravenous rituximab plus chemotherapy is standard treatment for diffuse large B-cell lymphoma. A subcutaneous formulation of rituximab is expected to simplify and shorten drug preparation and administration, and to reduce treatment burden. MabEase (clinicaltrials.gov Identifier: 01649856) examined efficacy, safety and patient satisfaction with subcutaneous rituximab plus chemotherapy in treat...

creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. creatine supplements have shown beneficial effects on neurological disorders including parkinson's disease, huntington's disease, amyotrophic lateral sclerosis, alzheimer's disease and stroke. however, the potential benefits of creatine for pati...

BACKGROUND Vitamin C at high concentrations is toxic to cancer cells in vitro. Early clinical studies of vitamin C in patients with terminal cancer suggested clinical benefit, but 2 double-blind, placebo-controlled trials showed none. However, these studies used different routes of administration. OBJECTIVE To determine whether plasma vitamin C concentrations vary substantially with the route...

INTRODUCTION Nicorandil has vasodilatory effects on both the epicardial coronary arteries and the coronary microvasculature, thereby increasing coronary blood flow. Intravenous administration of nicorandil can be applicable for fractional flow reserve (FFR) measurement as a hyperaemic agent and a possible alternative to adenosine. However, the effectiveness of intravenous nicorandil infusion fo...

conclusions intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. further larger studies are required. objectives this study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. patients and methods in a randomized double-blinded clinical trial, all patients ...

Early neonatal hypocalcemia is a common problem in prematurely born infants. To prevent it, therapy with intravenous calcium is often advised. We compared the efficacy and side-effects of intravenous and oral calcium supplementation in preterm and low birth-weight babies. Both the groups were comparable for birth weight, gestational age and cord blood calcium level. Oral calcium administration ...

These studies tested whether activation of central thromboxane (Tx)A2/prostaglandin (PG) H2 receptors raises blood pressure (BP). Messenger RNA for TxA2/PGH2 receptors was detected in normal Sprague-Dawley rat brain and in rat neuronal and astroglial brain cells in culture. The mean arterial blood pressure (MAP) was recorded in conscious rats during graded administration of the TxA2/PGH2 recept...

Spinal myoclonus with arteriovenous malformations (AVMs) of the spinal cord after intravenous administration of contrast material is extremely rare. Only one case of spinal myoclonus after intravenous infusion of contrast medium for computed tomography (CT) was found in our literature review [1]. We report a second case of spinal myoclonus and symptoms of a transverse spinal lesion consequent t...

the blood biochemical parameters were investigated in a yak (bos grunniens l) after intravenous administration of 5 mg/kg enrofloxacin. blood samples were collected from the jugular vein daily for 5 days after the drug administration. heparinized bloods were collected for mean corpuscular volume (mcv), erythrocyte sedimentation rate (esr), hemoglubin (hb) estimation and serum was collected for ...

Creatine exerts beneficial effects on a variety of pathologies in which energy metabolism and oxidative stress play an etiological role. Creatine supplements have shown beneficial effects on neurological disorders including Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, Alzheimer's disease and stroke. However, the potential benefits of creatine for patients with convu...