Tracheal granuloma can cause severe stenosis long after extubation. When a patient with a history of endobronchial intubation has an intratracheal tumour, we should consider the possibility of this condition.

Pulmonary absorption of phenol red was studied in normal subjects. Phenol red was administered by intratracheal injection and its urinary excretion was used as an index of pulmonary absorption. Doses ranging from 3 to 30 mg were given to two subjects and urinary phenol red excretion was found to be rate limited. That this effect occurred in the lung was shown by giving the dye intravenously to ...

A possible synergistic action between the carcinogen diethylnitrosamine injected s.c. and MgO, A12O3, or carbon instilled intratracheally in the respiratory tract of Syrian golden hamsters was studied. Diethylnitrosamine alone induced tumors of the nasal cavity in 50% of the animals. Tumors were also produced in the larynx and trachea but not in the lungs. Groups receiving weekly intratracheal ...

Evidence of endoplasmic reticulum (ER) stress has been found in lungs of patients with familial and sporadic idiopathic pulmonary fibrosis. We tested whether ER stress causes or exacerbates lung fibrosis by (i) conditional expression of a mutant form of surfactant protein C (L188Q SFTPC) found in familial interstitial pneumonia and (ii) intratracheal treatment with the protein misfolding agent ...

OBJECTIVES In this study, we focused on the qualitative and quantitative differences of the lung lesions induced by single or multiple intratracheal administration of nickel oxide nanoparticles (NiO). METHODS Male rats were randomized into groups receiving intratracheal administrations in a single dose or two to four divided doses of 2 mg/kg/bw. Bronchoalveolar lavage fluid (BALF) analyses we...

134 Journal of Anaesthesiology Clinical Pharmacology | Volume 33 | Issue 1 | January-March 2017 The perioperative anesthetic management is very challenging in patient of tracheal tumor especially with intratracheal mass due to ventilatory concerns and suitable airway gadget for securing airway. Also, the intratracheal mass may get detached and dislodged distally leading to distal airway obstruc...

An organism of the Pasteurella group (Pasteurella avicida) has been shown to possess considerable pathogenicity for rabbits when injected into the trachea. 1 cc. of bouillon containing 1/100 cc. of a 24 hour bouillon culture introduced by means of a curved metal tube passed through the larynx gives rise to a rapidly fatal septicemia in which the lungs are not particularly involved. Rabbits may ...

The effect of intratracheal administration of cyclooxygenase-1 (COX-1)-modified adipose stem cells (ASCs) on monocrotaline-induced pulmonary hypertension (MCT-PH) was investigated in the rat. The COX-1 gene was cloned from rat intestinal cells, fused with a hemagglutanin (HA) tag, and cloned into a lentiviral vector. The COX-1 lentiviral vector was shown to enhance COX-1 protein expression and ...

Intratracheal delivery of aerosolized monoclonal antibodies with specificity for Yersinia pestis LcrV and F1 antigens protected mice in a model of pneumonic plague. These data support the utility of inhaled antibodies as a fast-acting postexposure treatment for plague.

OBJECTIVE To assess the safety and feasibility of allogeneic human umbilical cord blood (hUCB)-derived mesenchymal stem cell (MSC) transplantation in preterm infants. STUDY DESIGN In a phase I dose-escalation trial, we assessed the safety and feasibility of a single, intratracheal transplantation of hUCB-derived MSCs in preterm infants at high risk for bronchopulmonary dysplasia (BPD). The fi...