ObjectiveTo assess the success rate, procedure time, and adverse events of intrathecal administration nusinersen via paramedian approach in adolescents adults with spinal muscular atrophy (SMA) associated scoliosis.MethodsSeven patients genetically confirmed SMA (age, 12–40 years) were included. Intrathecal was performed using fluoroscopy after determination largest interlaminal foramen among L...

FULLY implantable devices or drug–device combinations, such as intrathecal drug delivery (DD) systems and spinal cord stimulation (SCS) systems, increasingly are used for the treatment of chronic intractable pain. Another approved indication for intrathecal DD systems is the administration of intrathecal baclofen (ITB) to treat medically intractable spasticity of spinal or cerebral origin. Alth...

BACKGROUND Studies have reported that prophylactic continuous infusion of phenylephrine during spinal anesthesia for cesarean section can decrease the spread of local anesthetics. We investigated the ED50 of intrathecal hyperbaric ropivacaine in parturient women undergoing cesarean section under prophylactic infusion of phenylephrine. METHODS Sixty parturient women were allocated into 2 group...

BACKGROUND The degree to which intrathecally administered morphine can alleviate hypersensitivity in animals after peripheral nerve injury is controversial, and the mechanisms by which morphine works in these circumstances are uncertain. In normal animals, morphine induces adenosine release, and in vitro data suggest that this link is disrupted after peripheral nerve injury. Therefore, using a ...

Introduction: The use of epidural analgesia in patients with implanted intrathecal delivery devices is somewhat controversial. Major concerns include the risk of damaging the intrathecal catheter, the risk of infection, and the potential for interaction between the epidurally-administered and the intrathecally-delivered medication. In children with cerebral palsy, intrathecal administration of ...

ber 1999) that demonstrate little difference in dermatomal spread in CSF of fentanyl compared with morphine after intrathecal injection. Thus, the extrapolation from pigs to humans and from models of CSF and tissue kinetics to clinical effects is far from certain. In summary, the article by Ummenhofer et al. is a seminal work in intrathecal pharmacokinetics. It directly incorporates location in...

At the present time, anti-inflammatory, immunomodulatory, or immunosuppressive treatments of multiple sclerosis (MS) are mainly effective in the early phases of the disease but are of less advantage in progressive phases. Current therapeutic strategies of both primary and secondary progressive MS are rare. One alternative may be intrathecal application of triamcinolone acetonide (TCA). Number o...

Introduction The use of intrathecal morphine has the potential to help alleviate the pain that patients experience undergoing spinal surgeries. Complications can cause immobilization, which can lead to vascular thrombosis and ileus. Studies have shown epidural analgesia significantly lowered postoperative pain scores in scoliosis surgeries. Intrathecal anesthesia has been shown to have good pai...

BACKGROUND For their analgesic and anti-arthritic effects, Aconitum species have been used in folk medicine in some East Asian countries. Although their analgesic effect is attributed to its action on voltage-dependent sodium channels, they also suppress purinergic receptor expression in dorsal root ganglion neurons in rats with neuropathic pain. In vitro study also demonstrated that the Aconit...