To The Editor: I read with interest the series of articles addressing one of the most interesting debates in modern cardiology.1–3 Unfortunately, for the great majority of patients with acute ST-elevation myocardial infarction (STEMI) in Croatia, use of primary percutaneous coronary intervention (PCI) as a therapeutic option is still a daydream. As in other developing countries, this choice is ...

SIR,-Further to the interesting leading article "Nutrition and Sleep" (20 May, p. 418) one may ask whether sleep is not the "natural" state and wakefulness merely a res,pite for the satisfaction of instinctual (and socially inculcated) drives. The hibernating animal is unlikely to chance upon dangerous predators. On this model the satisfqction of drives would lead to sleep and their continued f...

PURPOSE 1) To describe the effectiveness and safety of thrombolytic therapy in patients with acute atherothrombotic and embolic stroke and 2) to study the variables of the occlusion site as seen on the angiograms, the CT signs of early ischemia, the hyperdense middle cerebral artery sign (HMCAS), and the size of the infarcts as seen on the 24-hour CT scan. METHODS Ninety-three of 139 patients...

BACKGROUND AND PURPOSE Multiple statistical analyses of the 2 NINDS-tPA trials have confirmed study findings of benefit of fibrinolytic therapy. A recent graphic analysis departed from best practices in the visual display of quantitative information by failing to take into account the skewed functional importance of NIH Stroke Scale raw scores and by scaling change axes at up to 20 times the ra...

INTRAPLEURAL MINOCYCLINE FOR SPONTANEOUS PTX? Current initial treatment for primary spontaneous pneumothorax (PTx) has a substantial rate of recurrence. In this study (Lancet 2013;381:1277–82), investigators randomly assigned patients with a first episode of PTx to receive minocycline pleurodesis or simple aspiration and drainage. At 1 year, 29.2% patients in the minocycline group had a recurre...

introduction: post operative pain is an unpleasant experience following various stimuli resulting in a response by the body. this process causes physiological disturbances in all of the systems of the body. methods and materials: in this clinical trial , 60 upper abdominal surgery patients were selected post operatively and divided into two groups of 30 patients each. in one group, bupivacaine ...

materials and methods in the present study, a potent nk-producing strain was isolated from cow milk and identified. to enhance the yield of nk, effect of various parameters such as ph, temperature, carbon source, nitrogen source and inoculum size were optimized. strain improvement of p. aeruginosa cmss was done by random uv-mutagenesis. nattokinase was partially purified and the activity was de...

Fibrinolytic treatment is the standard of care for eligible patients presenting early with acute ST segment elevation myocardial infarction (MI) to hospitals where rapid triage to primary angioplasty is unavailable. Although fibrinolytic treatment of elderly patients is generally accepted, a recent paper raised questions about its safety and efficacy. In this editorial, we will review the relev...