1. Marigo FA, Finger PT, McCormick SA, et al. Iris and ciliary body melanomas. Arch Ophthalmol. 2000;118:1515-1521. 2. SunbaMS,RahiAH,MorganG.Tumorsof theanterior uvea, I: metastasizing malignant melanoma of the iris. Arch Ophthalmol. 1980;98:82-85. 3. Planten JT. An unnecessary mistake. Ophthalmologica. 1970;160:369-371. 4. GrossniklausHE,BrownRH,StultingRD,etal. Iris melanomaseeding througha ...

Background: Currently, radiotherapy represents the most widely employed therapeutic option in patients with uveal melanoma. Although effects of proton beam on melanoma end ocular tissues have been histologically documented, their appearance at MR imaging is still poorly understood. The purpose our study was to elucidate magnetic resonance (MR) semiotics radiotherapy-induced changes neoplastic a...

Human embryonic stem cells (hESCs) provide a platform for studying human development and understanding mechanisms underlying diseases. Retinoblastoma-1 (RB1) is a key regulator of cell cycling, of which biallelic inactivation initiates retinoblastoma, the most common congenital intraocular malignancy. We developed a model to study the role of RB1 in early development and tumor formation by gene...

purpose : to compare the intraocular pressure (iop) lowering effect and side effects of xalatan with generic latanoprost (xalabiost) in adults with open-angle glaucoma or ocular hypertension methods : this was a two-center prospective randomized, crossover clinical trial. eligible patients with open-angle glaucoma or ocular hypertension were sequentially randomized to two parallel study groups ...

in 1991, handlers and colleagues described the central odontogenic fibroma (cof) as a distinct entity which is a rare benign odontogenic tumour and up to the present, only 78 cases of it have been published. cof usually occurs in an adult patient and has a predilection for the anterior region of the jaws. a 2.8:1 female to mail ratio is typically noted. this article presents a case of cof in a ...

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen and an angiogenic inducer as well as a mediator of vascular permeability. The biological effects of VEGF are mediated by two tyrosine kinase receptors, Flt-1 (VEGFr-1) and KDR (VEGFR-2). VEGF is essential for developmental angiogenesis and is also required for female reproductive functions and endochondral bone fo...

The retinoblastomais known as the most common intraocular malignancy of the childhood. In addition to other diagnostic methods theOptical Coherence Tomography (OCT) may be considered an important tool in the evaluation ofselective involvement of the retinaby small and medium sized tumors at the posterior pole of the eye.The authors present two cases of retinoblastoma in which the OCT was ableto...

92 CATARACT & REFRACTIVE SURGERY TODAY EUROPE SEPTEMBER 2011 A lthouth vitreoretinal lymphoma, retinal astrocytoma, and choroidal osteoma are rare diseases, they do occur. Therefore, it is important to have clinical suspicion of these entities because proper diagnosis may have important systemic and ocular implications. The general ophthalmologist must stay forever vigilant for causes of visual...

Photodynamic therapy (PDT) has been used for treatment of various intraocular tumors including choroidal hemangioma, vasoproliferative tumor, amelanotic choroidal melanoma and choroidal neovascular membrane due to choroidal osteoma. This case report documents the effect of PDT for a presumed acquired retinal astrocytoma. A 42-year-old female with a juxtapapillary acquired astrocytoma was treate...

Description of Procedure or Service Optical coherence tomography (OCT) is a high resolution method of imaging the ocular structures. OCT for the anterior eye segment is being evaluated as a non-invasive diagnostic and screening tool for the detection of angle closure glaucoma, to assess corneal thickness and opacity, evaluate pre-surgical and postsurgical anterior chamber anatomy, calculate int...