Topical administration of prostaglandin F2a (PGF2a) produced a reduction in intraocular pressure in eyes of rabbits, cats, and cynomolgus monkeys. In rabbit eyes at 5 or 6 hr, 50 ng, 100 ng, or 250 ng of PGF2a caused a significant intraocular pressure reduction with a small miotic effect. Treatment with 500 ng, 750 fig, or 1000 ng of PGF2a lowered intraocular pressure significantly in cat eyes ...

BACKGROUND The relationship between intraocular pressure and age is not fully understood. Intraocular pressure may increase or decrease with age. PURPOSE Study was planned to determine the effect of aging on intraocular pressure of an apparently healthy population of Karachi. SUBJECTS AND METHODS Depending upon age, 8036 subjects were divided into seven groups. All were examined according t...

OBJECTIVE To study the effects of sufentanil and fentanyl on intraocular pressure after easy and difficult intubations. METHODS From January 2006 to January 2008 there were included 120 patients undergoing general anesthesia at University Hospital Center (Mother Theresa) Service of Anesthesia and Intensive Care, Tirana, Albania. The patients were divided into 2 groups, 60 patients each receiv...

Introduction: The aim of present study was to assess the correlation between glucose and lipid biomarkers variations with biometric characteristics and intraocular pressure changes following Ramadan fasting. Methods: A total of 100 healthy fasting volunteers were enrolled in the study. Of them, 89 subjects completed the study with respect to inclusion and exclusion criteria. Right eye ocular ax...

BACKGROUND The aim of this study was to compare the efficacy and safety of micropulse and continuous wave diode transscleral cyclophotocoagulation in refractory glaucoma. DESIGN Randomized, comparative, exploratory study in a tertiary hospital setting. PARTICIPANTS Patients with refractory, end-stage glaucoma. METHODS Forty-eight patients were randomized to either treatment. The intraocul...

In rabbits the topical administration of sodium azide (NaNs) or sodium nitroprusside (SNP) increased intraocular pressure in a dose-response manner. These agents, which activate guanylate cyclase, elevated cyclic GMP in the aqueous humor. Systemic blood pressure and pulse were not altered. Tonographic outflow facility was unchanged, suggesting an increase in aqueous humor flow as the mechanism ...

AIM To investigate the influence of acute changes in intraocular pressure on the oxygen tension in the vicinity of the optic nerve head under control conditions and after intravenous administration of 500 mg of the carbonic anhydrase inhibitor dorzolamide. METHODS Domestic pigs were used as experimental animals. Oxygen tension was measured by means of a polarographic electrode in the vitreous...

About 1 diopter (D) myopic change was induced experimentally in rabbit eyes by raising the body temperature and increasing the intraocular pressure with a specially designed suction cup. The myopic changes only took place when the body temperature was 41 to 43° C, intraocular pressure was above 40 mm. Hg, and topical atropine was given. Eyes subjected to repeated high pressure after the initial...

The effect on intraocular pressure (IOP) from dogs pulling against a collar or a harness was evaluated in 51 eyes of 26 dogs. The force each dog generated while pulling against a collar or a harness was measured. Intraocular pressure measurements were obtained during application of corresponding pressures via collars or harnesses. Intraocular pressure increased significantly from baseline when ...