BACKGROUND Up to date, no information exists about the intra-articular temperature changes of the knee related to activity and ambient temperature. METHODS In 6 healthy males, a probe for intra-articular measurement was inserted into the notch of the right knee. Each subject was jogging on a treadmill in a closed room at 19 degrees C room temperature and skiing in a ski resort at -3 degrees C...

We demonstrated previously that local, intra-articular injection of an adenoviral vector expressing human tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in a rabbit knee model of inflammatory arthritis stimulated synovial apoptosis and reduced inflammation. To examine whether intra-articular injection of recombinant chimeric human TRAIL protein (rTRAIL) also induces apoptosis o...

It has been proposed that the process of hypoxic-reperfusion injury contributes to the persistence of synovitis in the inflamed human joint. The generation of pathological, exercise induced, intra-articular pressure leading to occlusion of the synovial microcirculation is central to this mechanism. However, acute traumatic inflammatory joint effusions rarely result in chronic synovitis, suggest...

in order to study the development of knee joint in absence of movement; mouse limb buds were separated from 15 days old embryos and cultured in ham's f-io medium conditioned with 37°c and 5% co2 for 1 to 6 days. the medium was renewed every 24h during incubation. after 6 days, specimens were fixed by buin's fluid, embedded in paraffin wax, serially sectioned and stained with h&e.; the...

conclusions intra-articular levobupivacaine-tenoxicam-morphine combination provides effective pain relief, longer analgesic duration, and less analgesic requirement when compared with intra-articular levobupivacaine-tenoxicam-tramadol combination and saline after knee arthroscopic surgery. results vasr and vasa were significantly higher in group s in comparison to other groups (p < 0.05). durat...

Two cases of acute rupture of the knee joint are reported after the intra-articular injection of radioactive yttrium 90. It is suggested that this may be a complication of intra-articular radioactive injections.

The use of intra-articular steroids in the treatment of osteo-arthritis of the knee joints has not been much discussed in the literature. Burgess (1957) states that intra-articular hydrocortone is of most value in joints distended by synovial fluid. Williams (1958) found that hydrocortisone tertiarybutylacetate was effective over a longer period than hydrocortisone, but that both might dramatic...

Objectives—CD4+ T cells sustain the chronic synovial inflammatory response in rheumatoid arthritis (RA). SB210396/CE 9.1 is an anti-CD4 monoclonal antibody that has documented eYcacy in RA when given intravenously. This study aimed to establish the safety and eYcacy of the intra-articular administration of SB-210396/CE 9.1 compared with placebo, examining its mode of action using a combined ima...

background/objective: despite the present routine treatment of septic arthritis with antibacterial agents, articular damage is persistent and frequently leads to loss of joint function.  the aim of this study was to assess the effect of intra-articular corticosteroids added to systemic antibiotics in the treatment of experimental staphylococcal knee joint infection in rabbits.   methods : thirt...