Intestinal ischemia-reperfusion (I/R) causes gut dysfunction characterized by decreased basement membrane integrity and decreased barrier function. Indeed, it has been reported that the absorption of several drugs is altered after intestinal I/R. Intestinal I/R also promotes multi-organ failure (MOF). The liver and kidney can be affected by MOF after intestinal I/R. However, little is known abo...

The intestinal epithelium is maintained by a population of rapidly cycling (Lgr5(+)) intestinal stem cells (ISCs). It has been postulated, however, that slowly cycling ISCs must also be present in the intestine to protect the genome from accumulating deleterious mutations and to allow for a response to tissue injury. Here, we identify a subpopulation of slowly cycling ISCs marked by mouse telom...

Nonsteroidal anti-inflammatory drugs (NSAIDs), including lowdose aspirin, are among the most widely prescribed medications, with approximately 30 million patients worldwide ingesting NSAID [1]. NSAID could cause small intestinal injury. It became clear from the studies of post-mortem samplesby Bjarnason and colleagues (1993) that NSAID use is alsoassociated with significant damage to the more d...

Complement-mediated neutrophil activation appears to play an important role in ischemia-reperfusion (I/R) injury in a variety of tissues, including the heart, lung, and small bowel. The objective of this study was to determine whether inhibition of the alternative and classic complement cascades by administration of soluble complement receptor 1 (sCR1) prevents the increased neutrophil stiffnes...

Intestinal barrier dysfunction remains a critical problem in patients with intracerebral hemorrhage (ICH) and is associated with poor prognosis. Ghrelin, a brain-gut peptide, has been shown to exert protection in animal models of gastrointestinal injury. However, the effect of ghrelin on intestinal barrier dysfunction post-ICH and its possible underlying mechanisms are still unknown. This study...

he incidence of the diverticulum of the small bowel varies from 0.2-1.3% in autopsy studies to 2.3% when assessed on enteroclysis. it occurs mostly in patients in the 6th decade of their life. of all the small bowel diverticuli, jejunal diverticulum is the most common type. this rare entity is usually asymptomatic. however, they may cause chronic non-specific symptoms for a long period of time ...

To investigate the role of polysaccharide from Acanthopanax senticosus (ASPS) in preventing lipopolysaccharide (LPS)-induced intestinal injury, 18 mice (at 5 wk of age) were assigned to three groups with 6 replicates of one mouse each. Mice were administrated by oral gavage with or without ASPS (300 mg/kg body weight) for 14 days and were injected with saline or LPS at 15 days. Intestinal sampl...

1. Abstract 2. Introduction 3. IDMT induced intestinal injury of piglets 3.1. General study protocol 3.2. Changes in the body weight of piglets challenged with IDMT 3.3. Changes in the hematological indexes of piglets challenged with IDMT 3.4. Intestinal lesions and alterations of intestinal histology in piglets challenged with IDMT 3.5. Redox status in the plasma and intestine challenged with ...

BACKGROUND Notch signaling plays a critical role in the maintenance of intestinal crypt epithelial cell proliferation. The aim of this study was to investigate the role of Notch signaling in the proliferation and regeneration of intestinal epithelium after intestinal ischemia reperfusion (I/R) injury. METHODS Male Sprague-Dawley rats were subjected to sham operation or I/R by occlusion of the...

NSAIDuse is limited due to the drugs' toxicity to the gastrointestinal mucosa, an action incompletely understood. Lower gut injury induced byNSAIDs is dependent on bile secretion and is reported to increase the growth of a number of bacterial species, including an enterococcal species,Enterococcus faecalis This study examined the relationships between indomethacin (INDO)-induced intestinal inju...