The main objective of the present study was to formulate gastroretentive effervescent sustained release drug delivery systems of risperidone floating tablets with the help of Methocel® K15, Ethocel® standard 7FP premium, Eudragit ® RS100 sustained release polymers to improve its safety profile, bioavailability and patient compliance. Risperidone floating tablets were formulated by wet granulati...

The purpose of the research was to formulate microspheres of acyclovir (ACV) using mucoadhesive polymers, sodium alginate and chitosan. Calcium chloride was used as the ionotropic gelling agent. Sodium alginate was crosslinked by calcium chloride leading to a slower release of the drug. Chitosan which is a cationic polymer interacted with sodium alginate, an anionic polymer, to form an interpol...

The gelatin/gum Arabic microcapsules encapsulating peppermint oil were prepared by complex coacervation using tannic acid as hardening agent. The effects of various parameters, including concentration of wall material, core material, tannic acid and tween80 were investigated on particle size and encapsulation efficiency. For statistical evaluation of the parameters, Taguchi method has been used...

Introduction: Recent advances in nanoscience and biomedicine have attracted tremendous attention over the past decade to design and construct multifunctional nanoparticles that combine targeting, therapeutic, and diagnostic functions with a single platform to overcome the problems of conventional techniques for diagnosis and therapy with minimal toxicity.   Materials ...

Song, Zhilin, Sukumar Vijayaraghavan, and Celia D. Sladek. Simultaneous exposure to ATP and phenylephrine induces a sustained elevation in the intracellular calcium concentration in supraoptic neurons. Am J Physiol Regul Integr Comp Physiol 291: R37–R45, 2006. First published January 26, 2006; doi:10.1152/ajpregu.00718.2005.—Vasopressin (VP) release from the hypothalamo-neurohypophyseal system ...

Modulation of the L-type current by sarcoplasmic reticulum (SR) Ca2+ release has been examined in patch-clamped mouse myotubes. Inhibition of SR Ca2+ release by inclusion of ryanodine in the internal solution shifted the half-activating voltage ( V 0.5) of the L-type current from 1.1 ± 2.1 to -7.7 ± 1.7 mV. Ruthenium red in the internal solution shifted V 0.5 from 5.4 ± 1.9 to -3.2 ± 4.1 mV. Ch...

In the pair of papers of which this is Part I, the agent-oriented modeling perspective to cope with biological complexity is discussed. Three levels of dynamics are distinguished and related to each other: dynamics of externally observable agent behavior, dynamics of internal agent processes, and dynamics of multi-agent organisations. Basic agent concepts to describe externally observable agent...

Considerable evidence in the literature demonstrates the exposure of humans to an unknown ethylating agent. Previous studies have demonstrated the presence of 7-ethyl-Gua and 3-ethyl-Ade in urine, 7-ethyl-dGuo and O4-ethyl-dThd in human lung, and ethylvaline in hemoglobin. Some studies also report higher levels of ethyl adducts in smokers than in nonsmokers, and there is convincing evidence for...

In the pair of papers of which this is Part I, the agent-oriented modeling perspective to cope with biological complexity is discussed. Three levels of dynamics are distinguished and related to each other: dynamics of externally observable agent behavior, dynamics of internal agent processes, and dynamics of multi-agent organisations. Basic agent concepts to describe externally observable agent...

Globally, governments spend significant amounts of money attempting to prevent or mitigate the negative impacts invasive species using different strategies, including classical biological control for that are widespread in landscape. Arriving at point biocontrol release requires investment time and funds research testing, success agent is uncertain. We present a numerical model designed assist ...