OBJECTIVE The aim of this study was to assess the suitability of high-resolution metabolomics (HRM) for measure of internal exposure and effect biomarkers from deployment-related environmental hazards. METHODS HRM provides extensive coverage of metabolism and data relevant to a broad spectrum of environmental exposures. This review briefly describes the analytic platform, workflow, and recent...

The signal for degradation of proteins in the endoplasmic reticulum (ER) is thought to be the exposure of internal domains which are buried when the protein has adopted its correct conformation and which are also exposed in assembly intermediates. This raises the question of why the intermediates are not degraded. We developed a system based on the peroxidase-catalyzed iodination of tyrosine re...

Exposition of the petrous part of the internal carotid artery (pICA) necessitates close control during surgery for proximal internal carotid artery aneurysms. The most difficult manipulation is the exposure of the internal carotid artery on the level of the carotid canal, and in most cases it is accompanied by local neurological complications in postoperative period that are results of the trau...

Routine internal dose exposures are typically (in the UK nuclear industry) less than external dose exposures: however, the costs of internal dosimetry monitoring programmes can be significantly greater than those for external dosimetry. For this reason decisions on when to apply routine monitoring programmes, and the nature of these programmes, can be more critical than for external dosimetry p...

Article history: Received 27 January 2017 Accepted 30 January 2017 Available online 1 February 2017 Compared to the exposure to the external environment, whether and how the internal endocrine environment can illicit intergenerational effects is less understood. Hyperandrogenism is a common endocrine disorder that happens in 5–10% of reproductive-aged women. Previous animal studies suggest that...

Characterization of exposure from emerging radio frequency (RF) technologies in areas where children are present is important. Exposure to RF electromagnetic fields (EMF) was assessed in three "sensitive" microenvironments; namely, schools, homes, and public places located in urban environments and compared to exposure in offices. In situ assessment was conducted by performing spatial broadband...

BACKGROUND Evidence for an association between exposure during pregnancy to trihalomethanes (THMs) in drinking water and impaired fetal growth is still inconsistent and inconclusive, in particular, for various exposure routes. We examined the relationship of individual exposures to THMs in drinking water on low birth weight (LBW), small for gestational age (SGA), and birth weight (BW) in single...