Postoperative cognitive decline is a clinical syndrome. Volatile anesthetics are commonly used during surgery. It is conceivable that volatile anesthetics may contribute to postoperative cognitive decline. Isoflurane can impair cognitive functions of animals under certain conditions. However, the mechanisms for this impairment are not clear. Here, male 18-month old Fisher 344 rats or 10-week ol...

BACKGROUND Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin-1β (IL-1β) is unclear in CKD patients. MATERIAL AND METHODS We conducted a cross-sectional study including 79 non-diabetic patients who received hemodialysis after the ...

Abstract Objective To observe the anti-inflammatory effect, as well effect on expression of microtubule-associated protein light chain 3B (LC3B) and Beclin-1 herbal cake-partitioned moxibustion in rats with experimental autoimmune thyroiditis (EAT). Methods Female Sprague-Dawley were randomly divided into a normal group modeling group. The EAT rat model was prepared by combination antigen immun...

OBJECTIVE The present study aimed to investigate whether sustained volume overload is capable of inducing persistent upregulation of cardiac cytokines including tumor necrosis factor alpha (TNF)-alpha, interleukin (IL)-1beta, interleukin (IL)-6 and transforming growth factor (TGF)-beta(1). METHODS AND RESULTS Volume overload-induced heart hypertrophy in rats was established by aortacaval fist...

To investigate the effects of carvacrol supplementation diets in rainbow trout induced by LPS, we measured gene expressions relative to pro-inflammatory and apoptosis in kidney and liver. Fish, which that were studied by four different treatments with three replicates each, was 44.71±1.33 gr. All fish were infected with E. coli LPS (25 µg ml-1) expect control and only carvacrol containing diet ...

Objective(s): To investigate the protective effect of glycyrrhizin (GL) on hepatic ischemia-reperfusion injury (HIRI).Materials and Methods: Forty SD rats were randomly divided into sham group, HIRI group, GL 100 mg/kg group, and GL 200 mg/kg group. The pathological alterations of liver tissue in each group were observed. The levels of a...

UNLABELLED Very little is known about the role of interleukin-1β (IL-1β) and interleukin-18 (IL-18) in urticaria. MATERIAL AND METHODS Serum levels of IL-1β, IL-1 receptor antagonist (IL-1RA), and IL-18 were measured in 56 children with urticaria and in 41 healthy subjects. RESULTS Serum IL-1β did not differ between children with acute urticaria and controls. Children with single episode of...

BACKGROUND AND PURPOSE Subarachnoid hemorrhage caused by cerebral aneurysm rupture remains a life-threatening emergency despite advances in treatment. However, the mechanisms underlying aneurysm initiation, progression, and rupture remain unclear. We developed a method to induce experimental cerebral aneurysms in rats, monkeys, and mice. Interleukin-1beta (IL-1beta) is a key inflammatory mediat...

Native and oxidized (OX) low-density lipoprotein (LDL) may contribute to the pathogenesis of age-related macular degeneration (AMD). In this study, we investigated the effects of lipoproteins, including n-LDL and OX-LDL, on the expression of inflammation factors, interleukin-6 (IL-6) and interleukin-1β (IL-1β), in vivo and in cultured retinal pigment epithelial (RPE) cells. The potential role o...

Overtraining (OT) may be defined as an imbalance between excessive training and adequate recovery period. Recently, a downhill running-based overtraining (OTR/down) protocol induced the nonfunctional overreaching state, which is defined as a performance decrement that may be associated with psychological and hormonal disruptions and promoted intramuscular and systemic inflammation. To discrimin...