Interferon-beta is one of the most widely prescribed disease-modifying therapies for multiple sclerosis patients. However, this treatment only partially effective, and a significant proportion patients do not respond to drug. This paper proposes an alternative fuzzy logic system, based on opinion neurology expert, classify relapsing–remitting as high, medium, or low responders interferon-beta. ...

background contamination of therapeutic recombinant proteins with residual host cell dna must be controlled under the regulatory standards. objectives the current study established a new rapid, sensitive real time polymerase chain reaction (pcr) approach to measure the reliably of the residual escherichia coli (e. coli) host cell genomic dna in the recombinant streptokinase and alfa interferon ...

background: interferon beta-la and -1b have been increasingly used for the treatment of multiple sclerosis (ms). the most frequent systemic adverse effects are flu-like symptoms. laboratory abnormalities include asymptomatic leukopenia and elevated hepatic transaminases. myelodysplastic syndrome (mds) refers to a spectrum of hematological disorders which can occur in different situations. sever...

this study investigated the in vitro production of interferon-γ, interleukin (il)-10, il-12, and il-13, after antigenic stimulation of the cells (with leishmania antigen and lipopolysaccharide) using whole blood from patients with cutaneous leishmaniasis lesions caused by leishmania tropica and in volunteers with history of cutaneous leishmaniasis. elisa results showed that the mean production ...

introduction various types of dermatological manifestations have been reported due to hepatitis c virus (hcv) infection and anti­hcv therapy. some of them have been described during ifn-based therapies. peg-ifn-α-2a/rbv combination is used as the international standard of treatment for hcv infection for a long time. the combination therapy yields an adverse-event profile similar to standard int...

conclusions the results of this study indicate that the rs12979860 cc genotype of il28b was associated with a response to peg-ifnα-2a/rbv combination therapy in azerbaijani patients with hcv-1b infection. therefore, host genetics may be useful in predicting the response to hepatitis c treatment. objectives the aim of the current study was to determine the relationship between rs12979860 polymor...

human interferon β (inf-β) is a member of cytokines family which different studies have shown its immunomodulatory and antiviral activities. in this study an expression vector was designed and constructed for expression of human inf-β-1b either in shake flasks and bench top bioreactor. the designed vector was constructed based upon pet-25b(+) with t7 promoter. recombinant human beta interferon ...

alpha-interferon therapy has been approved for treatment of chronic hepatitis c and b. candidates for treatment are patients with well-compensated liver disease and histologic evidences of chronic hepatitis who have demonstrated abnormal aminotransferase levels for more than 6 months. from 30 patients with chronic hepatitis with diseases prolonged more than 6 months, we selected only 16 patient...

objective sub acute sclerosing pan encephalitis (sspe), a progressive neurological disorder characterized by inflammation of the brain (encephalitis), is the result of an inappropriate immune response to the measles virus or measles vaccination. sspe usually develops 2 to 10 years after the original viral attack. some of the major signs and symptoms are mental deterioration, jerky movements, an...