We have identified a population of T lymphocytes in peripheral blood, Vδ1 TCRγδ T lymphocytes, which unexpectedly was uniquely expressing high production of interferon-γ in newly diagnosed, untreated multiple sclerosis (MS) patients. IFN-γ production in this population distinctly correlated to parameters of clinical disease activity, inflammation, and neuronal damage. These Vδ1 T lymphocytes be...

Abbreviations: RA: Rheumatoid Arthritis; CIA: Collagen-Induced Arthritis; IL-1β: Interleukin-1β; IL-6: Interleukin-6; IL-17A: Interleukin17A; IFN-γ: Interferon-γ; TNF-α: Tumor; Necrosis Factor-α; GM-CSF: Granulocyte-Macrophage Colony-Stimulating Factor; IL-8: Interleukin-8; MTX: Methotrexate; CSA: Cyclosporine; AZA: Azathioprine; LEF: Leflunomide; CFA: Complete Freund’s Adjuvant; ELISA: Enzyme ...

OBJECTIVE Imbalance of hematopoietic cell proliferation and apoptosis is one of the major causes of leukemia. Enhanced cell proliferation and reduced apoptosis lead to hemocytes accumulation. Fas/FasL signaling pathway promotes cell apoptosis. This study investigated the impact of interferon γ (IFN-γ) on chronic myelogenous leukemia cell proliferation and apoptosis to elucidate its interaction ...

The aim of the present study was to investigate the role of the JAK/STAT1 signaling pathway in suberoylanilide hydroxamic acid (SAHA)-mediated down-regulation of indoleamine 2,3-dioxygenase (IDO) in gallbladder carcinoma cells. We treated SGC-996 gallbladder carcinoma cells with IFN-γ and SAHA. Western blotting was used to detect the expression of...

not received.[15.20–15.40]Comparison of rituximab-mediated interferon-γproduction and cytotoxicity by human NK cellsSébastien Dall’Ozzo, Pierre Bardos, Hervé Watier and

Background: Entecavir (ETV) has been widely used in the clinical treatment of Hepatitis B Virus (HBV). However, whether ETV is helpful recovery T cell immune function remains unclear. Objectives: We aimed to assess effects on serum HBV-DNA, interferon-γ (IFN-γ), and pregenomic RNA (pgRNA) patients with infection. Methods: The data 300 HBV admitted from January 2017 2019 were retrospectively ana...