Recombinant human adenovirus serotype 5 (HAd5V) vectors are gold standards of T-cell immunogenicity as they efficiently induce also humoral responses to exogenous antigens, in particular when used in prime-boost protocols. Some investigators have shown that pre-existing immunity to adenoviruses interferes with transduction by adenoviral vectors, but the actual extent of this interference is not...

Almost all people in developed countries are exposed to metal nanoparticles (MeNPs) that are used in a large number of applications including medical (for diagnostic and therapeutic purposes). Once inside the body, absorbed by inhalation, contact, ingestion and injection, MeNPs can translocate to tissues and, as any foreign substance, are likely to encounter the innate immunity system that repr...

The integration of infectious disease epidemiology with community ecology is an active area of research. Recent studies using SI models without acquired immunity have demonstrated that predation can suppress infectious disease levels. The authors recently showed that incorporating immunity (SIR models) can produce a "hump"-shaped relationship between disease prevalence and predation pressure; t...

The heme peroxidase HPX15 is an evolutionary conserved anopheline lineage-specific gene. Previously, we found that this gene is present in the genome of 19 worldwide distributed different species of Anopheles mosquito and its orthologs are absent in other mosquitoes, insects, or human. In addition, 65-99% amino acid identity among these 19 orthologs permitted us to hypothesize that the function...

Title of dissertation: ELECTROMAGNETIC BANDGAP STRUCTURES FOR BROADBAND SWITCHING NOISE MITIGATION IN HIGH-SPEED PACKAGES Shahrooz Shahparnia, Doctor of Philosophy, 2005 Dissertation directed by: Professor Omar M. Ramahi Mechanical Engineering Department, Electrical and Computer Engineering Department For the past two decades, silicon-based complementary metal-oxide semiconductor (CMOS) technol...

objective(s) studies have described immunomedulatory effects of sun exposure and ultraviolet radiation on infectious and neoplastic diseases. here the effect of exposure to low potency radiation of sun on the course of leishmaniasis in mice was studied. materials and methods fifteen balb/c mice were exposed to suberythemogenic doses of sun (mean 180 mj/cm2/day of uvb) 2 months before and 4 mont...

background and objectives: brucellosis is an important health problem in developing countries and no vaccine is available for the prevention of infection in humans. because of clinically infectious diseases and their economic consequences in human and animals, designing a proper vaccine against brucella is desirable. in this study, we evaluated the immune responses induced by a designed recombi...

conclusions results indicated that the present vaccination program is insufficient for immunity against measles in this area. the general population immunity was lower than the necessary level for the elimination of measles. therefore, sero-epidemiological studies are necessary to organize national programs for control and elimination of measles. results overall, 821 (91.2%) of the studied popu...

We propose the multicarrier on–off keying (MC-OOK) as a bandwidth-efficient modulation method for frequency-hopped multiple-access (FHMA) communications. The motivation for using MC-OOK is that a more bandwidth-efficient modulation scheme allows a larger number of frequency slots, and thus provides a higher immunity against multiple-access interference in FHMA systems. We analyze the average bi...