Diabetes mellitus is among the top ten leading causes of death worldwide and remains a serious health problem. More than half billion people have diabetes, which occurs when body unable to produce insulin or due inefficient use produced insulin. To keep blood glucose levels within acceptable norm, with type 1 diabetes need daily injections Even though an indispensable drug in treatment its inje...

Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due their degradation in gastrointestinal tract and low transmucosal permeation. In this study, concept of an delivery device utilizing elastomeric material presented with potential increasing absorption insulin. Absorption enhancement intestine proposed as a result self-unfolding p...

Currently available models of insulin dynamics are mostly based on the classical compartmental structure and, thus, their physiological utility is limited. In this work, we describe the development of a physiologically based model and its application to data from 154 patients who underwent an insulin-modified intravenous glucose tolerance test (IM-IVGTT). To determine the time profile of endoge...