The aim of this study was to determine the prevalence of different auto-antibodies in adult, French cystic fibrosis (CF) patients and to look for a correlation between autoimmunity, patient characteristics and survival. The sera of 144 patients were screened for a wide range of antibodies. Clinical, biological and bacteriological characteristics and the cystic fibrosis transmembrane conductance...

Methods A 6-year-old boy affected by an overlap autoimmune syndrome characterized by facial skin lesions chilblain lupus like (histopathologically compatible with leukocytoclastic vasculitis), recurrent skin urticarial episodes and a severe lung disease (in the anatomopathological study is a linfoid intersticial neumonitis). He presents antinuclear antibodies positivity (maximum title reported ...

It is now widely recognized that cases of haemolytic anaemia of spontaneous or endogenous origin may be divided into two broad groups: those determined by a genetical cause resulting in the production of defective red cells, and those not so determined. Among the latter group of acquired haemolytic anaemias are cases in which there is evidence for the presence of antibodies active against the p...

precipitation. These three methods correlate well. The electrophoretic method was found to be the most suitable for the study of this antibody. Antibodies to gastric mucosa were demonstrated by complement fixation and immunofluorescence. The two methods gave good correlation, the latter being more sensitive. The antigen was localized in the cytoplasm of the parietal cells and was recovered in t...

After immunization with trinitrophenyl (TNP)-Ficoll, mice produced both anti-TNP antibodies and auto-anti-idiotype (auto-anti-Id) antibodies specific for the anti-TNP antibody. Older animals produced more auto-anti-Id than did young animals. When mice were exposed to a normally lethal dose of irradiation while their bone marrow (BM) was partially shielded, they survived and slowly (6 wk) regain...