objective: micro-rnas (mirnas) are a class of posttranscriptional regulators that play crucial roles in various biological processes. emerging evidence suggests a direct link between mirnas and development of several diseases including type 2 diabetes (t2d). in this study, we aimed to investigate the effect of predicted mirna and target genes on insulin resistance. materials and methods: this e...

retinol binding protein4 (rbp4) is a type of adipokine which transports vitamin a to serum. rbp4 could be a bridge between obesity and insulin resistance. this study aimed to investigate the effects of aerobic exercises on rbp4 serum's concentration and metabolic syndrome risk factors in obese women.twenty obese women with body max index 35.81±3.67kg/m2, fat percentage 43.98±4.02, and waist to ...

objectives insulin resistance has been considered as the most important component of type 2 diabetes mellitus (dm2). plants used in folk medicine to treat diabetes mellitus represent a viable alternative for the control of this disease. this study was aimed to examine the antidiabetic effects of three iranian medicinal plants i.e. urtica dioica, trigonella foenum-graecum and fumaria officinalis...

context hcv infection is strongly associated with development of insulin resistance and type-2 diabetes, however molecular mechanism of these associations is not known. the aim of this review was to conduct a comprehensive literature search to understand the nature of the association between hepatitis c virus (hcv) infection and insulin resistance (ir). we also explored the role of hcv core pro...

conclusions our study showed a significant association between h63d and c282y mutations and the risk of type 2 diabetes in iranian population. background type 2 diabetes (t2d) is a common metabolic disease caused by insulin secretion defects, which is associated with a variety of complications such as retinopathy, nephropathy, and neuropathy. objectives regarding the relationship between type 2...

in an effort to evaluate the hypoglycemic activity of t. polium, the crude extract was administered orally to a group of streptozotocin induced diabetic rats for 6 consecutive weeks. significant decrease in blood glucose by 64%, total bilirubin by 35%, glutamate oxaloacetate transferase by 48% and glutamate pyruvate transferase by 30% was observed compared to untreated diabetic rats. however, t...

conclusions the mathematical meaning of the two insulin-related biomarkers examined was the same, and the odds ratios of the two biomarkers were almost the same after adjustments for other independent variables. objectives a one-year follow-up study was conducted to determine the ability of the insulin-related biomarkers to predict the risk of mets development. patients and methods a total of 2...

objective(s)apelin is novel adipokine acting on apj receptor, regulated by insulin and tumor necrosis factor-alpha (tnf-alpha). plasma apelin levels are increased in obese subjects. the aim of this study was to investigate whether or not the aerobic exercise modifies the elevated plasma apelin levels in obese women.materials and methodstwenty obese women (bmi 32.2 ± 6.4 kg/m2) were selected by ...

background :many pregnant muslim women choose to fast during ramadan every year worldwide. this study aimed to examine the effect of ramadan fasting on serum leptin, neuropeptide y and insulin in pregnant women and find whether fasting during pregnancy could have a negative effect on the health of mothers and fetuses.   methods : this cross-sectional study was conducted on 39 healthy volunteer ...

abstract bckground: patients with obstructive sleep apnea (osa) are at risk of developing the fatty liver as a result of being overweight. several studies suggest that osa per se could be a risk factor for liver injury and ischemic hepatitis with osa. the osa is an independent risk factor for insulin resistance. therefore, we investigated liver enzymes and insulin resistance in patients with os...