Violaxanthin de-epoxidation, chlorophyll fluorescence quenching, and photosynthetic O(2) evolution in the presence of paraquat (Pq) were studied in intact attached leaves of Pq-susceptible, and Pq-resistant (PqR) biotypes of Erigeron canadensis under different light conditions. Initially, similar changes were induced in the two biotypes, but the effects relaxed only in the PqR plants, indicatin...

Paraquat (PQ) is one of the most used herbicide worldwide. Its cytotoxicity is attributed to reactive radical generation. Resveratrol (Res) and montelukast (MK) have anti-inflammatory and antioxidant properties. The protective effects of Res, MK, or their combination against PQ-induced acute liver injury have not been investigated before. Therefore, we explored the protective potential of Res a...

Paraquat (PQ(2+)) is a prototypic toxin known to exert injurious effects through oxidative stress and bears a structural similarity to the Parkinson disease toxicant, 1-methyl-4-pheynlpyridinium. The cellular sources of PQ(2+)-induced reactive oxygen species (ROS) production, specifically in neuronal tissue, remain to be identified. The goal of this study was to determine the involvement of bra...

Even though plasma paraquat (PQ) levels have known to be an informative predictor, many patients succumb at low PQ levels in acute PQ intoxication. This study was designed to see whether the high resolution computerized tomography (HRCT) of the lungs would be a predictive measure in acute PQ intoxication. HRCT of the lungs was obtained from 119 patients with acute PQ intoxication on 7 days afte...

Right Bol loops are loops satisfying the identity ((zx)y)x = z((xy)x), and right Bruck loops are right Bol loops satisfying the identity (xy)−1 = x−1y−1. Let p and q be odd primes such that p > q. Advancing the research program of Niederreiter and Robinson from 1981, we classify right Bol loops of order pq. When q does not divide p−1, the only right Bol loop of order pq is the cyclic group of o...

BACKGROUND A high prevalence of chloroquine-resistant Plasmodium vivax in Indonesia has shifted first-line treatment to artemisinin-based combination therapies, combined with primaquine (PQ) for radical cure. Which combination is most effective and safe remains to be established. METHODS We conducted a prospective open-label randomized comparison of 14 days of PQ (0.25 mg base/kg) plus either...

Paraquat (PQ) has been one of the most widely used herbicides in the world. PQ, when ingested, is toxic to humans and may cause acute respiratory distress syndrome. To investigate molecular perturbation in lung tissues caused by PQ, Sprague Dawley male rats were fed with PQ at a dose of 25 mg/kg body weight for 20 times in four weeks. The effects of PQ on cellular processes and biological pathw...

Edaravone, an antioxidant and radical scavenger, showed protective effects against oxidative stress-like condition. Paraquat (PQ) is toxic herbicide considerable evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PQ toxicity. In this study, protective effect of edaravone against PQ induced toxicity and reactive oxygen species (ROS) generation in A549 cells and l...

Previous studies have demonstrated that excessive reactive oxygen/nitrogen species (ROS/RNS)‑induced apoptosis is an important feature of the injury to the lung epithelium in paraquat (PQ) poisoning. However the precise mechanisms of PQ‑induced dysfunction of the mitochondria, where ROS/RNS are predominantly produced, remain to be fully elucidated. Whether globular adiponectin (gAd), a potent m...

Objective: Interleukin-17A (IL-17A) is a potent proinflammatory factor. Our study aimed to investigate the role of IL-17A on acute lung injury (ALI) induced by paraquat (PQ) and the potential way. Methods: A total of 180 female mice were randomly and evenly divided into 9 groups: Control group (NS), PQ groups (4 groups) and PQ+A b groups (4 groups). NS group mice were treated with equal volume ...