Objective(s): Injectable insulin is the most widely used therapy in patients with type 1 diabetes which has several disadvantages. The present study was aimed to evaluate the efficacy of injectable insulin on diabetes mellitus-related complications in comparison to orally encapsulated insulin nanoparticles.Materials and Methods: This stu...

Last decade has been a witness of gradual transformation in the field of craniofacial and dental tissue engineering from synthetic implants and tissue grafts to biomimetic biomaterial scaffolds, and injectable hydrogels. Indeed, a vast variety of biomaterials is available e.g. natural or synthetic polymers, extracellular matrix, self-assembling systems, hydrogels, or bio-ceramics. Each material...

Due to the high complexity of some treatments, there is a need develop drug-delivery systems that can release multiple drugs/bioactive agents at different stages treatment. In this study, thermoresponsive injectable dual-release system was developed with gellan gum/alginate microparticles (GG:Alg) within Pluronic hydrogel composed mixture F127 and F68. The increase in F68 ratio decrease lead hi...

Abstract Ridge preservation is universally acknowledged as the conventional method for post-extraction healing yet there are no standard materials ideal outcome. Herein, a composite gel comprising gelatin nanoparticles (GNPs) and injectable platelet-rich-fibrin (i-PRF) potential candidate extracted socket introduced. The combination of GNPs i-PRF not only possesses favorable mechanical properti...

BACKGROUND Osteonecrosis of the femoral head can lead to destruction of the hip joint and disabling arthritis in young adults, if left untreated. Among the salvage procedures, core decompression combined with bone graft substitutes is a viable option for joint preservation. The purpose of this study was to review the outcomes of using synthetic bone graft substitute (calcium sulfate and calcium...

This study aimed to develop an optimized depot injectable atorvastatin (ATR) biodegradable in situ gel (ISG) system with minimum initial burst using a central composite design. The factors selected were poly (d, l-lactide-co-glycolide) (PLGA) concentration (X1), molecular weight of polyethylene glycol (PEG) (X2), and PEG concentration (X3). The independent variables were the initial burst of AT...

Background: Behavior and substance addiction is one of the risk factors for deep vein thrombosis (DVT). The aim of this study investigating the relationship between the different clinical manifestations pattern of DVT with the way, the amount and duration of narcotic drugs in patients admitted to St. Alzahra Hospital in Isfahan, Iran, during 10 years. Methods: In a cross-sectional study we stud...