in the present study the distribution of rubella hemagglutination inhibition (hi) antibody titer in the sera of 1486 women of 18 to 25 years old residing in tehran were examined. sera were pretreated with acid washed kaolin and pigeon red blood cell. titers below 1:10 and in some studies below 1:20 are considered nonimmune to rubella. our results show that 10, 29% of studied population had hi a...

In order to identify novel high value antibacterial targets it is desirable to delineate whether the inactivation of the target enzyme will lead to bacterial death or stasis. This knowledge is particularly important in slow growing organisms, like mycobacteria, where most of the viable anti-tubercular agents are bactericidal. A bactericidal target can be identified through the conditional delet...

A real-time PCR genotypic assay was developed for the detection of isoniazid (INH) resistance in Mycobacterium tuberculosis. The assay detects mutations C(-15)T and, possibly, G(-24)T in the regulatory region of the inhA gene and proved as sensitive and specific as nucleotide sequencing in all the clinical isolates tested. Our assays mapped the mutations efficiently in 10 out of 35 resistant is...

Gilad Twig, Solomon A. Graf, Mark A. Messerli, Peter J. S. Smith, Seung H. Yoo, and Orian S. Shirihai Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston; BioCurrents Research Center, Program in Molecular Physiology, Marine Biological Laboratory, Woods Hole, Massachusetts; Department of Physiology, The Bruce Rappaport Faculty of Medicine, Techni...

Using aroyl hydrazides as a source of amine and substituted aromatic aldehydes as a carbonyl source, we have synthesized aroyl hydrazide derivatives by condensation reaction. The synthesized compounds were characterized by FT-IR, 1H-NMR and 13C-NMR spectral studies. The Synthesized compounds were subjected to antimicrobial and anti-oxidant activities. Finally, molecular docking study had been p...

Hyun-Chul Kim, 2 Maxim V. Polyakov, 4 and Micha l Prasza lowicz Department of Physics, Inha University, Incheon 22212, Republic of Korea∗ School of Physics, Korea Institute for Advanced Study (KIAS), Seoul 02455, Republic of Korea Institut für Theoretische Physik II, Ruhr-Universität Bochum, D–44780, Bochum, Germany† Petersburg Nuclear Physics Institute, Gatchina, St. Petersburg 188 300, Russia...

Many hormones that stimulate intracellular signaling pathways utilizing the second messenger cAMP affect gene expression in target cells through the activation of cAMP-responsive transcriptional regulatory proteins. Two of the best characterized of these are the cAMP-response element (CRE)-binding protein (CREB) and the CRE-modulatory protein (CREM). CREB and CREM are expressed as a family of p...