We usually perform animal studies to provide scientific data or to explain the mechanisms of traditional Korean medicines (TKM) based on their demonstrated efficacy in clinical application or as mentioned in old TKM literature. Similarly, we focus on toxic and safety aspects of TKM using preclinical models so as to promote them as effective over the counter (OTC) or ethical drugs. Often a presc...

It is possible to obtain a quality assurance (QA) of the dosimetry within a short time by using the new mathematical tools for a water phantom where dose measurements were made at two points only for a few square field sizes of the linear accelerator beam. The human body is not homogeneous. Water phantom makes it possible to create inhomogeneous phantoms by introducing blocks within it at suita...

During the cooking of beef, the genotoxic heterocyclic aromatic amines 2-amino-3,8-dimethylimidazo[4,5-/]quinoxaline (MelQx), 2amino-3,4,8-trimethylimidazo[4,5-/]quinoxaline (DiMelQx), and 2amino-l-methyl-6-phenylimidazo[4,5-6]pyridine (PhIP) are formed. Little is known about the fate of these compounds in humans or the factors affecting it. We have developed assays based on capillary column ga...

UNLABELLED The ability to estimate absorbed doses in experimental animals to which radiolabeled material has been administered may be important in explaining and controlling potential radiation toxicity observed during preclinical trials. Most previously reported models for establishing doses to small animals have been stylized and mathematically based. This study establishes dose factors for i...