The rapidly increasing amount of information on three-dimensional (3D) structures of biological macro-molecules has still an insufficient impact on genome analysis, functional genomics and proteomics as well as on many other fields in biomedicine including disease-related research. There are, however, attempts to make structural data more easily accessible to the bench biologist. As members of ...

In the present paper the concept of uncertain resources in experimental design is extended to situations in which the desire for additional information increases with the amount of experiments available. For a number of simple but relevant examples diierent strategies are compared and optimal designs are developed in the scope of the theory of generalized designs.