We sought to determine the relationships among intrarenal and systemic inflammation and renal disease in HIV. We compared paired serum and urinary levels (normalized to urine creatinine) of monocyte chemotactic protein-1 (MCP-1), regulated on activation normal T cell expressed and secreted (RANTES), interferon-γ-induced protein-10 (IP-10), interleukin-8 (IL-8), and β2-microglobulin (B2M) betwee...

At a population level, inflammatory markers have been shown to predict outcome and response to therapy in patients with atherosclerotic cardiovascular disease. However, current markers are not sufficiently sensitive or specific to provide clinical utility for managing individual patients. We hypothesize that measurement of multiple circulating disease-related inflammatory factors will be more i...

BACKGROUND Delirium has been hypothesized to be a central nervous system response to systemic inflammation during a state of blood-brain barrier compromise. The purpose of this study was to compare postoperative changes in groups of inflammatory markers in persons who developed delirium following cardiac surgery and matched controls without delirium. METHODS Serum samples were drawn from 42 p...

BACKGROUND There is growing evidence that higher levels of inflammatory markers are associated with physical decline in older persons, possibly through the catabolic effects of inflammatory markers on muscle. The aim of this study was to investigate the association between serum levels of inflammatory markers and loss of muscle mass and strength in older persons. METHODS Using data on 2,177 m...

The blood-brain barrier (BBB) plays an important role in the clinical expression of neuropsychiatric symptoms during systemic illness in health and neurological disease. Evidence from in vitro and preclinical in vivo studies indicate that systemic inflammation impairs blood-brain barrier function. In order to investigate this hypothesis, we evaluated the association between systemic inflammator...

OBJECTIVES Acute laboratory stressors elicit elevations in serum levels of interleukin-6 (IL-6) and C-reactive protein (CRP). Chronic stressors, such as family dementia caregiving, promote a state of chronic low-grade elevation in circulating inflammatory markers. The recurrent daily stressors associated with chronic stress may lead to repeated and sustained activation of the physiological stre...

Patients with chronic inflammatory disorders (ID) have an increased risk of developing cardiovascular disease, and routinely determined parameters do not reveal the real metabolic status of specific subgroups, such as patients with rheumatoid arthritis (RA). In this study, in order to evaluate state of the art markers for the assessment of cardiometabolic risk, abnormalities in lipoprotein leve...

Chronic inflammation is a pathophysiological cause of age-related diseases including sarcopenia. However, limited data are available on the association between diet-derived and Here, using Dietary Inflammatory Index (DII), we examined associations inflammatory potentials diet, sarcopenia/its components, serum markers. This cross-sectional study was performed in 2014 among 1,254 community-dwelli...