The liver constitutes the first barrier in the control of hematogenous dissemination for Candida albicans of intestinal origin. The ability of this organ to limit the growth of the yeast and to mount an efficient inflammatory reaction is crucial in determining the outcome of the fungal infection. When rats infected with C. albicans are exposed to chronic varied stress, the cell recruitment is i...

Patients with coeliac disease (CD) on a gluten-free diet may still have gastrointestinal symptoms. On clinical grounds cow's milk (CM) protein sensitivity may be suspected. Here, using rectal protein challenge, we investigated the local inflammatory reaction to gluten and CM protein in adult patients with CD in remission. Rectal challenges with wheat gluten and dried CM powder were performed in...

Staphylococcal protein A (SpA) is representative of a new class of antigens, the B-cell superantigens (SAgs). These antigens bind to the Fab regions of immunoglobulin molecules outside their complementarity-determining regions. SpA, the best-studied B-cell SAg, reacts with the Fabs of most VH3+ immunoglobulins, which are expressed on 30 to 60% of human peripheral B cells. Therefore, B-cell SAgs...

objective: annexin a1 (anxa1) is suggested to have anti-inflammatory function. however, the precise function of anxa1 has remained unclear. in this study, we therefore examined the potency of anxa1 in regulating reactive oxygen species (ros) production and suppressing pro-inflammatory responses in pc12 cells induced by 1-methyl-4-phenylpyridinium (mpp+). materials and methods: in this experimen...

PURPOSE Thermographic assessment of temperature distribution within the examined tissues allows a quick, noncontact, noninvasive measurement of their temperature. The aim of the study was to evaluate the usefulness of digital infrared imaging in monitoring experimental inflammation of pleura (PL), lower lip (LL), and left paw (LP) and right paw (RP) of lower limbs in rats. MATERIALS AND METHO...

Abstract Background IL-37 is an anti-inflammatory cytokine that increases in several inflammatory diseases with the main inducing signal for its production being pro-inflammatory cytokines like TNF-?. We aimed to assess correlation between peritoneal fluid levels of and TNF-? endometriosis patients investigate their association disease stage. Levels were assessed 50 23 endometriosis-free female...

The aim of the research: to optimize treatment patients with combined genital pathology, including internal endometriosis (adenomyosis) and inflammatory diseases. Materials methods: prospective study has been conducted on 160 women adenomyosis. There were 24 (15 %) I degree adenomyosis spreading, 72 (45.0 II degree, 33 (20.6 III 31 (19.4 woman IV spreading. Microbial flora analysis included bac...

Several monocyclic ?-lactams have been synthesized via a [2+2] ketene–imine cycloaddition reaction (Staudinger reaction) and evaluated for their biological activities. The structure of products was confirmed by spectral data elemental analyses. ?-Lactams 4 b h exhibited 31 27 anti-inflammatory ratios, respectively, which are as well the well-known dexamethasone corticosteroid with 32 ratio. two...

BACKGROUND/AIMS The Arthus type allergic reaction is characterised by inflammatory cell infiltration and marked neovascularisation in the cornea. During the healing stages, inflammatory cells and newly formed microvessels gradually disappear. The aim was to establish whether apoptosis affected the regression of inflammatory cells and newly formed microvessels, in order to define more clearly th...

Stevens-Johnson syndrome is a rare but serious medical condition, which classified within the blistering diseases of skin and mucous membranes. It characterized by severe generalized immune-mediated inflammatory reaction, predominantly affecting membranes, such as eyes, mouth genitalia.