statement of problem: periodontal disease (pd) has been linked to adverse cardiovascular events by unknown mechanisms. c-reactive protein (crp) is a prognostic marker for cardiovascular disease, with reported elevated serum levels during pd. purpose: the aim of the present study was to evaluate the association between pd and higher crp levels in the serum of acute myocardial infarction (ami) pa...

Transforming growth factor (TGF)-beta(1) is a pleiotropic cytokine/growth factor that is thought to play a critical role in the modulation of inflammatory events. We demonstrate that exogenous TGF-beta(1) can inhibit the expression of the proinflammatory adhesion molecule, E-selectin, in vascular endothelium exposed to inflammatory stimuli both in vitro and in vivo. This inhibitory effect occur...

Matricaria chamomilla contained oils, sterols, triterpenes, flavonoids, saponins, tannins, alkaloids, sugars, proteins, mucins, sesquiterpenes, coumarins, polyacetylenes, phenyl carboxylic acids, amino phytosterols, choline and mineral substances. The pharmacological studies revealed that possessed dermatological, antioxidant, anticancer, anti-inflammatory, analgesic, antimicrobial, reproductiv...

Gingival enlargement is an inflammatory response to plaque present on tooth surfaces or due factors like drugs and several systemic conditions. In cases where the local are responsible subgingival scaling root planing do not help, gingivectomy/gingivoplasty performed which creates a raw wound heals slowly. Since surgical practice primarily depends upon healing of these wounds without serious co...

A critical function of the epithelial lining is to form a barrier that separates luminal contents from the underlying interstitium. This barrier function is primarily regulated by the apical junctional complex (AJC) consisting of tight junctions (TJs) and adherens junctions (AJs) and is compromised under inflammatory conditions. In intestinal epithelial cells, proinflammatory cytokines, for exa...

The S100 family of EF-hand calcium (Ca(2+))-binding proteins is essential for a wide range of cellular functions. During infection, certain S100 proteins act as damage-associated molecular patterns (DAMPs) and interact with pattern recognition receptors to modulate inflammatory responses. In addition, these inflammatory S100 proteins have potent antimicrobial properties and are essential compon...

Purpose: Osteoarthritis is the most common cause of arthritis affecting millions people worldwide, characterized by joint pain, which a major driver clinical decision making and health service use. Initially considered as simple degenerative erosive process cartilage, concept has migrated from local cartilage problem caused wear tear, to complex disease involving inflammatory factors whole incl...

The intensity and duration of macrophage-mediated inflammatory responses are controlled by proteins that modulate inflammatory signaling pathways. MCPIP1 (monocyte chemotactic protein-induced protein 1), a recently identified CCCH Zn finger-containing protein, plays an essential role in controlling macrophage-mediated inflammatory responses. However, its mechanism of action is poorly understood...

Molecular effects of sterol-enriched wheat bran oil (eWBA) on lipid metabolism, inflammatory markers, and liver proteome associated with nonalcoholic/metabolic-related fatty disease (MAFLD) are not completely known. In this study, dietary eWBA intervention was used to investigate its effect in ameliorating injury high fat diet (HFC)-fed C57BL/6 mice. Specifically, we examined eWBA’s (i) differe...