Artificially regulating gene expression is an important step in developing new treatment for system-level disease such as cancer. In this paper, we propose a method to regulate gene expression based on sampled-data measurements of gene products concentrations. Inherent noisy behaviour of Gene regulatory networks are modeled with stochastic nonlinear differential equation. To synthesize feed...

We consider approximation of L p functions by Hardy functions on subsets of the circle, for 1 p < 1. After some preliminaries on the possibility of such an approximation which are connected to recovery problems of the Carleman type, we prove existence and uniqueness of the solution to a generalized extremal problem involving norm constraints on the complementary subset. problems in Hardy spaces.

The windsurfing approach to iterative control requires a series of controller designs with the gradual expanding of the closed-loop bandwidth, and in the end in order to stop the algorithm, some validation tests are carried out. In this paper, an H1 design algorithm is introduced in order to remove the empirical aspect from the stopping criteria and to make the procedure more systematic, hence ...

Let a function f 2 L p ?1; 1], 0 < p 1 have 1 r < 1 changes of monotonicity. For all suuciently large n, we construct algebraic polynomials p n of degree n which are comonotone with f, and such that kf ? p n k Lp?1; 1] C(r)! ' 2 (f; n ?1) p , where ! ' 2 (f; n ?1) p denotes the Ditzian-Totik second modulus of smoothness in L p metric.