PURPOSE Coleus amboinicus is a medicinal plant traditionally used to treat various diseases such as throat infection, cough and fever, diarrhea, nasal congestion and digestive problems. The plant was explored for endophytic fungi producing antimicrobial agents. METHODS Screening for endophytic fungi producing antimicrobial agents was conducted using agar plug method and antimicrobial activity...

We review here the selectively infective phage (SIP) technology, a powerful tool for the rapid selection of protein-ligand and peptide-ligand pairs with very high affinities. SIP is highly suitable for discriminating between molecules with subtle stability and folding differences. We discuss the preferred types of applications for this technology and some pitfalls inherent in the in vivo SIP me...

Blood culture-negative endocarditis is common in Algeria. We describe the etiology of infective endocarditis in this country. Samples from 110 cases in 108 patients were collected in Algiers. Blood cultures were performed in Algeria. Serologic and molecular analysis of valves was performed in France. Infective endocarditis was classified as definite in 77 cases and possible in 33. Causative age...

An infective aetiology, including fungal infection, should be considered in the differential diagnosis of immunocompromised patients presenting with skin lesions. Dematiaceous fungi are recognised as pathogens in organ transplant recipients. Herein, we describe a rare case of a chronic necrotising granulomatous skin lesion caused by Pyrenochaeta romeroi in a renal transplant recipient, and revi...

community-acquired pneumonia and brucellosis are of the main agents causing mortality in the world. the most important limitations for the identification of these agents include their high resistance against environmental conditions, impossibility of rapid and on time diagnosis, low level of infective dose, and lack of existence of vaccine against many types of them. hence, on time action and d...

Pharmacokinetic interactions involving anti-infective drugs may be important in the intensive care unit (ICU). Although some interactions involve absorption or distribution, the most clinically relevant interactions during anti-infective treatment involve the elimination phase. Cytochrome P450 (CYP) 1A2, 2C9, 2C19, 2D6 and 3A4 are the major isoforms responsible for oxidative metabolism of drugs...

Recent interest in the relationship of fungi to human disease, both as infecting agents and as incitants of phenomena of hypersensitivity, induced us to undertake a detailed study of a patient who presents an uncommon skin lesion which appears to be associated with sensitivity to at least six species of non-pathogenic fungi. Passive transfer antibodies for these fungi were present in the patien...