The complex interaction between a microbial pathogen and a host is the underlying basis of infectious disease. By understanding the molecular details of this interaction, we can identify virulence-associated microbial genes and hostdefense strategies and characterize the cues to which they respond and mechanisms by which they are regulated. This information will guide the design of a new genera...

The need for novel approaches to treat infectious diseases is obvious and urgent. This situation has renewed interest in the use of monoclonal antibodies (mAbs) to treat infectious diseases. During the last 5 years, radioimmunotherapy (RIT), a modality developed for cancer treatment, has been successfully adapted for the treatment of experimental fungal (C. neoformans and H. capsulatum), bacter...

mental, and demographic changes during the 20th century have affected the health of women. Many of the changes have benefited women's health, but some have had deleterious effects. Infectious diseases pose an especially formidable threat to women, claiming >15 million lives around the globe each year (1). For many infectious diseases, women are at higher risk and have a more severe course of il...

Infectious diseases represent an ever-changing field of practice. Virtually each week brings new information, some with the potential to adjust or reinvent the current clinical practice. It is our task as clinicians to browse through field literature, through reports of randomized controlled trials, excerpts of conference proceedings, and to choose relevant scoops with high applicability in pat...

statisticians to contribute to the understanding and much remains unknown about properties of the tious disease data presents several challenges stem from the lack of detail and the dependence in data. Infectious disease data do not result from planned experiments, but arise from makes it diflicult to accumulate precise data and n lacking in detail. Another reason for the lack only partially ob...

There is a historical association between wetlands and infectious disease that has led to the modification of wetlands to prevent disease. At the same time there has been the development of water resources projects that increase the risk of disease. The demand for more water development projects and the increased pressure to make natural wetlands economically beneficial creates the need for an ...

Ricardo Molina, Debashis Ghosh, Eugenia Carrillo, Séverine Monnerat, Caryn Bern, Dinesh Mondal, and Jorge Alvar World Health Organization Collaborating Centre for Leishmaniasis, Laboratory of Medical Entomology, National Centre for Microbiology, Instituto de Salud Carlos III, Madrid, Spain; International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka; World Health Organizat...

Perhaps no other field of research has been more energized by the application of genomic technology than the field of microbiology. Five years ago, The Institute for Genomic Research published the first complete genome sequence for a free-living organism, Haemophilus influenzae (1). Since then, 27 more microbial genome sequences (2-28) and 3 lower eukaryotic chromosome sequences (29-31) have be...