After mouse mammary tumor virus (MMTV) infection, B lymphocytes present a superantigen (Sag) and receive help from the unlimited number of CD4(+) T cells expressing Sag-specific T-cell receptor Vbeta elements. The infected B cells divide and differentiate, similarly to what occurs in classical B-cell responses. The amplification of Sag-reactive T cells can be considered a primary immune respons...

semang (sag), a mutation isolated as a suppressor of Drosophila Src42A, has previously been shown to affect some receptor tyrosine kinase mediated embryonic processes. Here we show that sag specifically affects the development of R1, R6 and R7 photoreceptor cells in a cell-autonomous manner. These cells are absent in the mutant at the time when they normally appear in the ommatidial pre-cluster...

Power quality issues have been a source of major concern in recent years due to extensive use of power electronic devices and non-linear loads in electrical power system. In power systems the common disturbances are voltage sags and swells, usually associated with power system faults. Therefore the effective detection of voltage sags and swells event is an important issue for both voltage sag a...

Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony gluconate (SAG), are still the first choice for chemotherapy against various forms of leishmaniasis, including visceral leishmaniasis, or kala-azar. Although the requirement of a somewhat functional immune system for the antileishmanial action of antimony was reported previously, the cellular and molecular mechani...

Neuroblasts of the statoacoustic ganglion (SAG) initially form in the floor of the otic vesicle during a relatively brief developmental window. They soon delaminate and undergo a protracted phase of proliferation and migration (transit-amplification). Neuroblasts eventually differentiate and extend processes bi-directionally to synapse with hair cells in the inner ear and various targets in the...

Unlike immortalized cell lines, normal human fibroblasts in culture undergo replicative senescence in which the number of population doublings is limited. While fibroblasts display a variety of changes as they senesce in vitro, little is known about how gene expression varies as a function of population doubling level. We have used differential hybridization screening to identify human genes th...

Light-emitting Diode (LED) lamps are more versatile and energy efficient compared with conventional light sources. This paper investigates two main problems related to power quality, namely, the harmonic generation from LED lamps and the effect of voltage sags on LED lamps. Laboratory tests on various LED lamps are conducted and the electrical characteristics of LED lamps are tapped under diffe...

Intrathymic expression of endogenous mouse mammary tumor virus (MMTV)-encoded superantigens (SAg) induces the clonal deletion of T cells bearing SAg-reactive T-cell receptor (TCR) Vbeta elements. However, the identity of the thymic antigen-presenting cells (APC) involved in the induction of SAg tolerance remains to be defined. We have analyzed the potential of dendritic cells (DC) to mediate th...

Ivan Sag died on September 10, 2013, after a long illness. He is survived by his wife, Stanford sociolinguistics professor Penny Eckert. In a career spanning four decades, he published over 100 articles and 10 books, centered on the theme of developing precise, implementable, testable, psychologically plausible, and scalable models of natural language, especially syntax and semantics. Sag earne...

Repair of severe skin tissue injury remains a great challenge and wound infection is still formidable problem. In this study, new macroporous antibacterial gelatin/alginate (SAG)-based hydrogels for repair were designed developed based on in-situ gas foaming method ion release strategy as result Mg-Cu particles degradation in the hydrogel matrix. The addition decreased storage modulus SAG, main...