septicaemia caused by gram-negative pathogens is a dangerous infection which is associated with high incidence of liver dysfunction. the severe and acute hepatotoxicity is presumably due to massive release of endotoxin into systemic circulation after bacterial killing. the direct toxic effect of endotoxin is probably due to the increased production of reactive oxygen intermediates as o 2 - , pe...

amodiaquine is an antimalarial drug used in the prophylaxis and treatment of this disease. however, hepatotoxicity as a life‑threatening adverse effect is associated with its clinical use. we evaluated amodiaquine-induced toxicity in isolated rat hepatocytes as an in vitro model for studying drug‑induced hepatotoxicity. this study attempts to investigate the protective effects of taurine and n-...

to investigate the saturation induced collapse deformation behavior of rockfill material, a set of large-scale triaxial tests were conducted in saturated and dry-saturated conditions. specimens were tested under various confining pressures. for dry-saturated tests, specimens were sheared in various stress levels. results of all dry saturated tests indicate a sudden reduction in the specimen vol...

Stress is an insidious health risk that is commonly reported among university students. While research suggests that dog exposure may facilitate recovery from a stress response, little is known about the buffer effect of dog exposure on the stress response to a future stressor. This study examined whether interaction with a therapy dog could reduce the strength of the physiological stress respo...

The shear-induced microstructure of a shear-induced phase separating (SIPS) wormlike micellar solution is measured by combining small-angle neutron scattering with a shear cell capable of gap-resolved measurement in the 1-2 (velocity-velocity gradient) plane. Quantitative results show evidence for shear-induced microphase separation accompanied by shear banding. The results suggest both concent...

HEAT AND HYDRATION MAY NOT BE THE FIRST CONSIDERATIONS OF TOURNAMENT DIRECTORS, COACHES, AND ATHLETES, WHEN PREPARING FOR TENNIS. HOWEVER, HEALTH RISKS AND PERFORMANCE DECREMENTS ARE ASSOCIATED WITH BOTH. THE DEMANDS OF TENNIS, PARTICULARLY DURING MULTIDAY TOURNAMENTS, PREDISPOSE PLAYERS TO INCREASED CORE BODY TEMPERATURE AND LARGE FLUID LOSSES. THIS COMBINATION OF FACTORS CAN LEAD TO DECREASED...

Objective: The aim of this study was to investigate the effect of pre-treatment with curcumin on metabolic changes induced by two different pathophysiological mechanisms in rats (fructose diet and streptozotocin (STZ)-induced diabetes mellitus). Materials and Methods: Five groups with 10 rats per group were investigated: control group (healthy rats), fructose diet groups without any pre-treatme...

exposure to stress leads to physiological changes called “stress response” which are the result of the changes in the adrenomedullary hormone system, hypothalamus-pituitary-adrenal (hpa) and sympathetic nervous system (sns) activity. in the present study, the effects of chronic physical and psychological stress and also the role of sympathetic system effects in stress on ischemia/reperfusion (i...

introduction: many studies have been performed to evaluate the stress distribution around endodontic posts; those which compared posts composed of different materials are rare. the aim of this study was to compare stresses induced in dentin by three structurally different posts using photoelasticity method. materials and methods: nine blocks of psm-5 photoelastic material with 45×45×10 mm dimen...