Persistent states are believed to be the correlate for short-term or working memory. Using a previously derived model for working memory, we show that disruption of the lateral inhibition can lead to a variety of pathological states. These states are analogs of reflex or pattern-sensitive epilepsy. Simulations, numerical bifurcation analysis, and fast-slow decomposition are used to explore the ...

The role of L-DOPA in spinal nociceptive reflex activity has been re-evaluated. In high spinal cats, with supraspinal loops being excluded, the onset of reflex facilitation induced by noxious radiant heat is delayed after injection of L-DOPA by 4 to 10 s, i.e. the early component of nociceptive reflex facilitation is blocked, while the late component persisted. Further investigations have shown...

PURPOSE Photosensitive epilepsy (PSE) is a form of reflex epilepsy characterized by seizures triggered by light. Genetic factors play an important role and some studies have indicated a possible role of the bromodomain-containing protein 2 (BRD2) gene. Our aim was to investigate the relationship between PSE and mutations of the BRD2 gene. METHODS Fifty-four PSE patients with normal findings o...

Temporal epilepsy is a common neurological disorder that begins before adulthood. Two -way factors in causing epilepsy and continuing attacks can be inflammation that is caused by immune system and infection. The hippocampus and amygdala are part of a limbic system that relies on memory and emotional regulation. The purpose of this study was to review the effect of epileptic-induced inflammatio...

Background and Objective: In temporal lobe epilepsy (TLE), recurrent seizures accompany with cognitive deficit. In some patients, the current medications cannot provide satisfactory control of seizures, therefore new drugs that act through different mechanisms are required. In the present study, the useful effect of dipeptidyl peptidase-4 inhibitor was evaluated in experimental model of tempora...

Commentary The ILAE has redefined epilepsy: epilepsy is a disease of the brain causing at least two unprovoked or reflex seizures occurring more than 24 hours apart or after one seizure if risks of recurrence are " high " (>60%). Conversely—and making a change that carries significant implications—they also now define epilepsy as " resolved " if an individual has outgrown their age-dependent sy...

Sudden unexpected death in epilepsy (SUDEP) has been identified as one of the most prevalent causes mortality epilepsy, and SUDEP consequently become an important topic research. The appear multifactorial, including epilepsy-induced cardiac arrest. Current understanding autopsy negative sudden unexplained (SUD) general population its relation to arrhythmic syndrome (SADS) could shed some light ...

AIMS To investigate the diagnoses made for children referred to a "fits, faints, and funny turns" clinic. METHODS Prospective study of 380 children referred to a dedicated secondary care clinic over an eight year period. RESULTS Twenty three per cent of children were given a final diagnosis of one of the childhood epilepsies, with 48% of these having a specific epilepsy syndrome. Syncope wa...