Ventricular arrhythmia was once regarded uncommon in infants and children, since most cardiac arrests were thought to be hypoxia-induced bradycardia followed by asystole. Furthermore, ischemic heart disease, the basis for many of the ventricular arrhythmias in adults, is rare in pediatric patients. However, with the advent of pediatric critical care, improved techniques of extracorporeal life s...

The Ca2+ release channel ryanodine receptor 2 (RyR2) is required for excitation-contraction coupling in the heart and is also present in the brain. Mutations in RyR2 have been linked to exercise-induced sudden cardiac death (catecholaminergic polymorphic ventricular tachycardia [CPVT]). CPVT-associated RyR2 mutations result in "leaky" RyR2 channels due to the decreased binding of the calstabin2...

STUDY OBJECTIVE Incidence of spontaneous cardiac arrhythmias and inducibility of ventricular arrhythmias in the cardiomyopathic hamster, BIO 14.6 strain, were examined. DESIGN A 3 min electrocardiogram (ECG) was recorded weekly to 50 weeks of age. Programmed ventricular stimulation was then performed with single and double ventricular premature stimuli during both sinus rhythm and ventricular...

The relationship between chemotherapy and arrhythmias has not been well established. We reviewed the existing literature to better understand this connection. We reviewed published reports on chemotherapy-induced arrhythmias in English using the PubMed/Medline and OVID databases from 1950 onwards as well as lateral references. Arrhythmias were reported as a side effect of many chemotherapeutic ...

Electrophysiologic studies were performed in 172 consecutive patients for evaluation of documented sustained ventricular tachyarrhythmias. One hundred thirteen patients presented with sustained ventricular tachycardia that was hemodynamically stable, and 59 patients presented with cardiac arrest. Seventy-one patients without previously documented or suspected ventricular arrhythmias were also s...

background: cardiac failure is the major lethal consequence of aluminum phosphide (alp) poisoning. this study was designed to determine the frequency of cardiac arrhythmias in patients with alp poisoning. methods: in this prospective cross-sectional study, patients with definitive history of alp poisoning treated at emergency department of allied hospital faisalabad, faisalabad, pakistan, from ...

objective: to determine the type and pattern of arrhythmic events following the 2012 ahar-varzegan earthquake among patients implanted with cardiac defibrillators (icds) in east azarbaijan province. methods: in a prospective cohort study, conducted in east azerbaijan province of iran, 132 patients were enrolled in two comparison groups according to the region of residence i.e., earthquake regio...

flecainide has been known to cause torsades de pointes (tdp) in patients with structural heart disease and its mechanism has been attributed to use-dependency. we present a patient with flecainide-induced tdp in the absence of any other precipitating factors.this case highlights potential reverse use dependence associated with flecainide resulting in tdp.

Previous results from our laboratory showed that phosphorylation of ryanodine receptor 2 (RyR2) by Ca(2+) calmodulin-dependent kinase II (CaMKII) was a critical but not the unique event responsible for the production of reperfusion-induced arrhythmogenesis, suggesting the existence of other mechanisms cooperating in an additive way to produce these rhythm alterations. Oxidative stress is a prom...

Epidemiological studies show that particulate matter (PM) is the principal instigator of some adverse clinical symptoms involving cardiovascular diseases. PM exposure can increase experimental infarct size and potentiate myocardial ischemia and arrhythmias in experimental MI models such as ischemia-reperfusion (I/R) injury.The present study was aimed to evaluate the effects of particulate matte...