The study aimed to investigate the gastroprotective activity of ethyl acetate fraction derived from stem bark extract Desert date tree (EFDD) (Balanites aegyptiaca L. Delile; family Zygophyllaceae) using ethanol and indomethacin-induced ulcer models in Wistar rats. was conducted rats divided them into five groups (n=5). Group 1 received 10% Tween 20 (1 ml/kg), which served as control group. 2 a...

Raphanus sativus L. ‘Radish’ locally known as Fijl, is a Brassicaceous plant of cabbage family which has been reputed for its benefic medicinal properties. The present study was undertaken to evaluate the freshly squeezed Radish juice (FRJ) for its anti-gastric ulcer activity in experimental models, besides preliminary qualitative phytochemical screening. Oral administration of FRJ in doses of ...

BACKGROUND Herbal medicines are now recently used as treatment options. This study was conducted to determine the effect of the combination therapy of medicinal herbs in the treatment of induced gastrointestinal injury among albino wistar rats. METHODS A total of 60 Albino Wistar rats of both sexes weighing between 130g-150g were used. The control groups which consisted of negative control gr...

Chromolaena odorata (C. odorata) (L.) R. King & H. Robinson is a perennial flowering shrub with diverse habitats, including crops, grasslands, and roadsides. This plant has been widely used in Vietnamese folk medicine for gastric ulcer treatment. Hence, the present study aimed to evaluate acute toxicity anti-ulcer effect of ethanol crude extract C. leaves its fractions against indomethacin-...

This study examined the effects of indomethacin and rofecoxib on normal and Helicobacter pylori (H. pylori)-infected gastric mucosa of Mongolian (M.) gerbils. M. gerbils (6-wk-old) were orally administered H. pylori (ATCC43504, 2 x 10(8) CFU/ml) after fasting for 24 hours. Beginning 3 mo after inoculation, indomethacin (2 mg/kg, s.c) or rofecoxib (10 mg/kg, p.o.) was administered once daily for...

Ulcers are the most common form of GI disorder that is often caused by either inflammation or infection that certainly affected 10% of the population at risk. Among all types of ulcers, peptic ulcer is the more catastrophic one. This point made an exemption objective to conduct an investigation for antiulcer activity of alcoholic extract of Garuga pinnata leaves in rats. Acute gastric lesions i...

Pomegranate (Punica granatum L.) belongs to genera Punica and family Punicaceae. It is a herbal preparation that has been suggested as useful in the treatment of gastrointestinal disorders. However, to our knowledge, no study has been conducted to evaluate this therapeutic property. In the present study the antiulcerogenic effects of pomegranate peel methanol extract, was tested on male Wistar ...

Abstract Ghrelin has been shown to ameliorate gastric injury by several mechanisms in experimental animal models. The present study aimed to investigate the effect of pretreatment with ghrelin on indomethacin induced gastric injury in rats and the role of heme oxygenase -1(HO-1) pathway as a novel mechanism underlying the gastroprotective effect of ghrelin. In all groups studied, ulcer score (U...

The high risk of developing gastric ulcers by various non-steroidal anti-inflammatory drugs has affected their common application in the treatment of collagen diseases like arthritis. Indomethacin, a potent anti inflammatory agent, has been found to induce gastric irritation and ulceration (1). In humans, it is expected that pregnancy which may exert physiologic stress would aggravate gastric u...

Aim: To evaluate the ability of red and white hibiscus (H) in improving epithelial barrier indomethacin-induced duodenal colonic inflammation, compared with prebiotic to investigate whether and/or can be used as natural like agents. Methods: Histological, histomorphometric, histochemical demonstration for goblets cells mucin intensity. Immunohistochemical COX-2, tight junctions (Claudin-1 E-cad...