Interkingdom signaling is established in the gastrointestinal tract in that human hormones trigger responses in bacteria; here, we show that the corollary is true, that a specific bacterial signal, indole, is recognized as a beneficial signal in intestinal epithelial cells. Our prior work has shown that indole, secreted by commensal Escherichia coli and detected in human feces, reduces pathogen...

We report our joint computational and anion photoelectron spectroscopic study of indole-water cluster anions, indole(H2O)1,2 (-). The photoelectron spectra of both cluster anions show the characteristics of dipole-bound anions, and this is confirmed by our theoretical computations. The experimentally determined vertical electron detachment (VDE) energies for indole(H2O)1 (-) and indole(H2O)2 (-...

3-Carboxy-1-sulfopyridin-1-ium chloride ([CPySO3H]+Cl-) as a novel ionic organocatalyst for thecondensation of aldehydes and 2-methylindole to synthesize bis(2-methyl-1H-indole) derivatives inacetonitrile at room temperature has been developed. Some tetrakis (2-methyl-1H-indole)derivatives have also been synthesized by the reaction of 2,2'-(butane-1,4-diylbis(oxy))dibenzaldehyde and 2-methylind...

the present study aims at indicating the existence and uniqueness result of system in extended colombeaualgebra. the caputo fractional derivative is used for solving the system of odes. in addition, rieszfractional derivative of colombeau generalized algebra is considered. the purpose of introducing rieszfractional derivative is regularizing it in colombeau sense. we also give a solution to a n...

Indole has recently been implicated as an important small molecule signal utilized by many bacteria to coordinate various forms of behavior. Indole plays a role in numerous bacterial processes, including: biofilm formation and maintenance, virulence factor production, antibiotic resistance and persister cell formation. Intercepting indole-signaling pathways with appropriately designed small mol...

A variety of intercellular signal molecules, such as, the most studied N-acyl-homoserinelactones (AHLs) in Gram-negative bacteria, autoinducer (AI-2) in both Gram-negative and Gram-positive bacteria, and signal peptides in Gram-positive bacteria, have been discovered over the last 20 years. Although it has been known for over 100 years that many bacteria produce indole, the real biological role...

The tryptophan metabolites indole, indole-3-acetate, and tryptamine were identified in mouse cecal extracts and fecal pellets by mass spectrometry. The aryl hydrocarbon receptor (AHR) agonist and antagonist activities of these microbiota-derived compounds were investigated in CaCo-2 intestinal cells as a model for understanding their interactions with colonic tissue, which is highly aryl hydroc...

background and objectives: the essential amino acid l-tryptophan can be produced by a condensation reaction between indole and l-serine, catalyzed by b. subtilis with tryptophan synthase activity. application of the tryptophan is widespread in the biotechnology domain and is sometimes added to feed products as a food fortifier. materials and methods: the optimum concentration of the iranian can...

Bipolar resistive switching using organic molecule is very promising for memory application owing to their advantages like simple device structure, low manufacturing cost, stability and flexibility etc. Herein we report Langmuir-Blodgett spin-coated film based bipolar devices material indole derivative. Pressure - area per isotherm, Brewster Angle Microscopy, Atomic Force Microscopy Scanning El...